Hypofunctional dopamine uptake and antipsychotic treatment-resistant schizophrenia
Antipsychotic treatment resistance in schizophrenia remains a major issue in psychiatry.
Nearly 30% of patients with schizophrenia do not respond to antipsychotic treatment, yet the …
Nearly 30% of patients with schizophrenia do not respond to antipsychotic treatment, yet the …
Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 …
K Blagotinšek Cokan, M Mavri, CS Rutland, S Glišić… - Biomolecules, 2020 - mdpi.com
The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor
(GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by …
(GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by …
Multi-electrode array analysis identifies complex dopamine responses and glucose sensing properties of substantia nigra neurons in mouse brain slices
N Mannal, K Kleiner, M Fauler, A Dougalis… - Frontiers in synaptic …, 2021 - frontiersin.org
Dopaminergic (DA) midbrain neurons within the substantia nigra (SN) display an
autonomous pacemaker activity that is crucial for dopamine release and voluntary …
autonomous pacemaker activity that is crucial for dopamine release and voluntary …
Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder
R Chen, MJ Ferris, S Wang - Pharmacology & therapeutics, 2020 - Elsevier
Abstract Dopamine D2 autoreceptors (D 2 ARs), located in somatodendritic and axon
terminal compartments of dopamine (DA) neurons, function to provide a negative feedback …
terminal compartments of dopamine (DA) neurons, function to provide a negative feedback …
NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra …
C Simons, J Benkert, N Deuter, C Poetschke… - Frontiers in molecular …, 2019 - frontiersin.org
Neuronal Ca2+ sensor proteins (NCS) transduce changes in Ca2+ homeostasis into altered
signaling and neuronal function. NCS-1 activity has emerged as important for neuronal …
signaling and neuronal function. NCS-1 activity has emerged as important for neuronal …
Cortical mediation of relationships between dopamine receptor D2 and cognition is absent in youth at risk of bipolar disorder
Bipolar disorder is associated with cognitive deficits and cortical changes for which the
developmental dynamics are not well understood. The dopamine D2 receptor (DRD2) gene …
developmental dynamics are not well understood. The dopamine D2 receptor (DRD2) gene …
G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D2 receptor desensitization
R Ågren, K Sahlholm - The FASEB Journal, 2021 - diva-portal.org
The dopamine D2 receptor (D2R) functions as an autoreceptor on dopaminergic cell bodies
and terminals and as a postsynaptic receptor on a variety of neurons in the central nervous …
and terminals and as a postsynaptic receptor on a variety of neurons in the central nervous …
Co‐activation of GPCRs facilitate GIRK‐dependent current
AF Condon, N Asad, TM Dore… - The Journal of …, 2022 - Wiley Online Library
The activity of dopamine neurons is dependent on both intrinsic properties and afferent
projections. One potent form of inhibition is mediated by the activation of two inhibitory G …
projections. One potent form of inhibition is mediated by the activation of two inhibitory G …
The regulation of alternative pre-mRNA splicing, activity-induced splicing and adaptive splicing by DNA methylation
L Liu - 2021 - mspace.lib.umanitoba.ca
Many molecular bases for the long-term adaptive changes in cells remain unknown.
Alternative splicing contributes dramatically to protein diversity and allows for the fine-tuning …
Alternative splicing contributes dramatically to protein diversity and allows for the fine-tuning …
[图书][B] Enhanced Dopamine Autoreceptor Functioning During Blockade of Dopamine Transporters
RL Pace - 2021 - search.proquest.com
Dopamine autoreceptors (DARs) and dopamine transporters (DATs) influence dopamine
transmission in the brain's mesolimbic pathway. Prior studies have focused on how …
transmission in the brain's mesolimbic pathway. Prior studies have focused on how …