Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?
The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …
Preparation, quality criteria, and properties of human blood platelet lysate supplements for ex vivo stem cell expansion
DTB Shih, T Burnouf - New biotechnology, 2015 - Elsevier
Most clinical applications of human multipotent mesenchymal stromal cells (MSCs) for cell
therapy, tissue engineering, regenerative medicine, and treatment of immune and …
therapy, tissue engineering, regenerative medicine, and treatment of immune and …
[HTML][HTML] Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
Aging associates with impaired pancreatic islet function and increased type 2 diabetes
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …
[HTML][HTML] Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic …
Background Epigenetic factors regulate tissue-specific expression and X-chromosome
inactivation. Previous studies have identified epigenetic differences between sexes in some …
inactivation. Previous studies have identified epigenetic differences between sexes in some …
[HTML][HTML] Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets
Genetic and epigenetic mechanisms may interact and together affect biological processes
and disease development. However, most previous studies have investigated genetic and …
and disease development. However, most previous studies have investigated genetic and …
[HTML][HTML] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
Aims/hypothesis To date, the molecular function of most of the reported type 2 diabetes-
associated loci remains unknown. The introduction or removal of cytosine–phosphate …
associated loci remains unknown. The introduction or removal of cytosine–phosphate …
[HTML][HTML] Principal criteria for evaluating the quality, safety and efficacy of hMSC-based products in clinical practice: current approaches and challenges
JA Guadix, J López-Beas, B Clares, JL Soriano-Ruiz… - Pharmaceutics, 2019 - mdpi.com
Human Mesenchymal Stem Cells (hMSCs) play an important role as new therapeutic
alternatives in advanced therapies and regenerative medicine thanks to their regenerative …
alternatives in advanced therapies and regenerative medicine thanks to their regenerative …
Glucose-induced changes in gene expression in human pancreatic islets: causes or consequences of chronic hyperglycemia
Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be
causally involved in the development of hyperglycemia, or it could develop as a …
causally involved in the development of hyperglycemia, or it could develop as a …
[HTML][HTML] DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets
E Hall, T Dayeh, CL Kirkpatrick, CB Wollheim… - BMC medical …, 2013 - Springer
Background Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1
(GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of …
(GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of …
[HTML][HTML] Reflections on dry eye syndrome treatment: therapeutic role of blood products
Dry eye syndrome (DES) is a multifactorial, frequent, pathology characterized by deficient
tear production or increased evaporation of tears and associated with ocular surface …
tear production or increased evaporation of tears and associated with ocular surface …