Metabolism of arsenic and its toxicological relevance
T Watanabe, S Hirano - Archives of toxicology, 2013 - Springer
Arsenic is a worldwide environmental pollutant and a human carcinogen. It is well
recognized that the toxicity of arsenicals largely depends on the oxidoreduction states …
recognized that the toxicity of arsenicals largely depends on the oxidoreduction states …
What is the best biomarker to assess arsenic exposure via drinking water?
N Marchiset-Ferlay, C Savanovitch… - Environment …, 2012 - Elsevier
Arsenic (As) is a ubiquitous element. The current WHO guideline for As in drinking water is
10μg/L. Furthermore, about 130 million people have only access to drinking water …
10μg/L. Furthermore, about 130 million people have only access to drinking water …
Xenobiotics: interaction with the intestinal microflora
K Lu, R Mahbub, JG Fox - ILAR journal, 2015 - academic.oup.com
The human body is host to 100 trillion gut microbes, approximately 10-times more than all
human cells. It is estimated that the approximately 500–1000 species residing in the human …
human cells. It is estimated that the approximately 500–1000 species residing in the human …
Arsenic metabolism and thioarsenicals
K Rehman, H Naranmandura - Metallomics, 2012 - academic.oup.com
Arsenic has received considerable attention in the world, since it can lead to a multitude of
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …
Thiolated arsenicals in arsenic metabolism: Occurrence, formation, and biological implications
Y Sun, G Liu, Y Cai - Journal of Environmental Sciences, 2016 - Elsevier
Arsenic (As) is a notoriously toxic pollutant of health concern worldwide with potential risk of
cancer induction, but meanwhile it is used as medicines for the treatment of different …
cancer induction, but meanwhile it is used as medicines for the treatment of different …
Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells
H Naranmandura, K Ibata… - Chemical research in …, 2007 - ACS Publications
Chronic ingestion of arsenic-contaminated drinking water induces skin lesions and urinary
bladder cancer in humans. It is now recognized that thioarsenicals such as …
bladder cancer in humans. It is now recognized that thioarsenicals such as …
Thiolated arsenic in natural systems: What is current, what is new and what needs to be known
Thiolated arsenic compounds are the sulfur analogous substructures of oxo-arsenicals as
the arsinoyl (As= O) is substituted by an arsinothioyl (As= S) group. Relatively brief history of …
the arsinoyl (As= O) is substituted by an arsinothioyl (As= S) group. Relatively brief history of …
Arsenic metabolism and thioarsenicals in hamsters and rats
H Naranmandura, N Suzuki, K Iwata… - Chemical Research …, 2007 - ACS Publications
The tissue distribution and chemical forms of arsenic were compared in two animal species
with different metabolic capacity and toxicity to arsenic. Hamsters and rats were given a …
with different metabolic capacity and toxicity to arsenic. Hamsters and rats were given a …
Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals
TS Pinyayev, MJ Kohan, K Herbin-Davis… - Chemical research in …, 2011 - ACS Publications
The conventional scheme for arsenic methylation accounts for methylated oxyarsenical
production but not for thioarsenical formation. Here, we report that in vitro anaerobic …
production but not for thioarsenical formation. Here, we report that in vitro anaerobic …
Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells
H Naranmandura, Y Ogra, K Iwata, J Lee… - Toxicology and Applied …, 2009 - Elsevier
Arsenic toxicity is dependent on its chemical species. In humans, the bladder is one of the
primary target organs for arsenic-induced carcinogenicity. However, little is known about the …
primary target organs for arsenic-induced carcinogenicity. However, little is known about the …