Genome-wide molecular studies have provided new insights into the organization of nuclear
chromatin by revealing the presence of chromatin domains of differing transcriptional …

The human genome folds to create thousands of intervals, called" contact domains," that
exhibit enhanced contact frequency within themselves." Loop domains" form because of …

Enhancers can regulate the promoters of their target genes over very large genomic
distances. It is widely assumed that mechanisms of enhancer action involve the …

While Mediator plays a key role in eukaryotic transcription, little is known about its
mechanism of action. This study combines CRISPR-Cas9 genetic screens, degron assays …

Cellular responses to low oxygen (hypoxia) are fundamental to normal physiology and to the
pathology of many common diseases. Hypoxia-inducible factor (HIF) is central to this by …

Limb-specific Shh expression is regulated by the (∼ 1 Mb distant) ZRS enhancer. In the
mouse, limb bud-restricted spatiotemporal Shh expression occurs from∼ E10 to E11. 5 at …

Poly (ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme
involved in the regulation of the chromatin structure and transcription. PARP-1 consists of …

Integration of binding information by macromolecular entities is fundamental to cellular
functionality. Recent work has shown that such integration cannot be explained by pairwise …

It is proposed that the multiple enhancer elements associated with locus control regions and
super‐enhancers recruit RNA polymerase II and efficiently assemble elongation competent …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …