RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Abstract mRNA medicine is a new and rapidly developing field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …

Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

The 3′-end processing machinery for metazoan replication-dependent histone precursor
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …

Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …