MicroRNA signatures in human cancers
MicroRNA (miRNA) alterations are involved in the initiation and progression of human
cancer. The causes of the widespread differential expression of miRNA genes in malignant …
cancer. The causes of the widespread differential expression of miRNA genes in malignant …
Heritability in the genomics era—concepts and misconceptions
PM Visscher, WG Hill, NR Wray - Nature reviews genetics, 2008 - nature.com
Heritability allows a comparison of the relative importance of genes and environment to the
variation of traits within and across populations. The concept of heritability and its definition …
variation of traits within and across populations. The concept of heritability and its definition …
Understanding mechanisms underlying human gene expression variation with RNA sequencing
Understanding the genetic mechanisms underlying natural variation in gene expression is a
central goal of both medical and evolutionary genetics, and studies of expression …
central goal of both medical and evolutionary genetics, and studies of expression …
Child health, developmental plasticity, and epigenetic programming
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …
survival and reproductive success to the organism under changing environments …
microRNA target prediction programs predict many false positives
According to the current view, each microRNA regulates hundreds of genes. Computational
tools aim at identifying microRNA targets, usually selecting evolutionarily conserved …
tools aim at identifying microRNA targets, usually selecting evolutionarily conserved …
Mapping complex disease traits with global gene expression
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
A genome-wide association study of global gene expression
We have created a global map of the effects of polymorphism on gene expression in 400
children from families recruited through a proband with asthma. We genotyped 408,273 …
children from families recruited through a proband with asthma. We genotyped 408,273 …
Genetic analysis of genome-wide variation in human gene expression
Natural variation in gene expression is extensive in humans and other organisms, and
variation in the baseline expression level of many genes has a heritable component. To …
variation in the baseline expression level of many genes has a heritable component. To …
Revealing the architecture of gene regulation: the promise of eQTL studies
Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool
for identifying genetic variants that affect gene regulation. In these studies, expression levels …
for identifying genetic variants that affect gene regulation. In these studies, expression levels …
High-resolution mapping of expression-QTLs yields insight into human gene regulation
JB Veyrieras, S Kudaravalli, SY Kim… - PLoS …, 2008 - journals.plos.org
Recent studies of the HapMap lymphoblastoid cell lines have identified large numbers of
quantitative trait loci for gene expression (eQTLs). Reanalyzing these data using a novel …
quantitative trait loci for gene expression (eQTLs). Reanalyzing these data using a novel …