Mitochondrial dysfunction underlines a multitude of pathologies; however, studies are
scarce that rescue the mitochondria for cellular resuscitation. Exploration into the protective …

Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading
cause of end-stage renal disease. Abnormal lipid metabolism and intrarenal accumulation of …

Rationale: After adjustment for the amount of smoking, women have a 50% increased risk of
chronic obstructive pulmonary disease (COPD) compared with men. The anatomic basis …

An essential feature of Alzheimer's disease (AD) is implicated in brain energy metabolic
impairment that is considered underlying pathogenesis of cognitive impairment. Therefore …

Abstract Zn 2+ deficiency (ZnD) is comorbid with chronic kidney disease and worsens
kidney complications. Oxidative stress is implicated in the detrimental effects of ZnD …

Recently, research has directed its interests into identifying molecular pathways implicated
in calcineurin inhibitor (CNI)-induced renal fibrosis. An emerging body of studies …

Intracranial aneurysm (IA) is a frequent cerebrovascular disorder with unclear pathogenesis.
The vascular smooth muscle cells (VSMCs) phenotypic switch is essential for IA formation. It …

Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, the
complication of diabetes in the kidney. NADPH oxidases of the Nox family, and in particular …

Heart failure (HF) is a functional lack of myocardial performance due to a loss of molecular
control over increases in calcium and ROS, resulting in proteolytic degradative advances …

As a transcriptional activator widely expressed in various tissues, nuclear factor of activated
T cells (NFAT) is involved in the regulation of the immune system, the development of the …