Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Targeted therapies by means of compounds that inhibit a specific target molecule represent
a new perspective in the treatment of cancer. In contrast to conventional chemotherapy …

Radiation therapy is a staple cancer treatment approach that has significantly improved local
disease control and the overall survival of cancer patients. However, its efficacy is still limited …

Laboratory studies that led to the development of epidermal growth factor receptor (EGFR)
inhibitors indicated that such inhibitors would be effective when given to patients with …

Growth factor receptors and their ligands not only regulate normal cell processes but have
been also identified as key regulators of human cancer formation. The epidermal growth …

US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

Novel therapeutic agents that target the epidermal growth factor receptor (EGFR) constitute
an important addition to the therapeutic armamentarium for the treatment of metastatic …

Purpose: Gemcitabine-radiotherapy is a standard treatment for locally advanced pancreatic
cancer. Clinical data have shown that gemcitabine plus erlotinib is superior to gemcitabine …

Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of
Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3: E2 complex …

Purpose: Recently, activating mutations of the epidermal growth factor receptor (EGFR)
gene were discovered in non–small cell lung cancers sensitive to gefitinib (ZD1839, an …