Recent developments in antimalarial activities of 4-aminoquinoline derivatives

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2023 - Elsevier
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

Quinoline: a promising scaffold in recent antiprotozoal drug discovery

A Dorababu - ChemistrySelect, 2021 - Wiley Online Library
Protozoal infections malaria and leishmania have become most prevalent in recent times. A
high death rate is reported world‐wide because of these diseases. Although there are only a …

Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …

H Madhav, TS Patel, Z Rizvi, GS Reddy… - European Journal of …, 2023 - Elsevier
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

H Madhav, N Hoda - European Journal of Medicinal Chemistry, 2021 - Elsevier
Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half
of million deaths annually. The eradication of malaria is one of the global health priority …

Optimal weak measurement scheme for chiral molecular detection based on photonic spin Hall effect

T Tang, K Shen, J Li, X Liang, Y Tang, C Li, Y He - Optics Express, 2023 - opg.optica.org
In this paper, we propose a precision method to measure the chiroptical signal of Artemisinin
solutions using the photonic spin Hall effect (PSHE) on the Ce: YIG-YIG-SiO_2 structure as a …

The chemistry of triazine isomers: structures, reactions, synthesis and applications

N Kushwaha, CS Sharma - Mini reviews in medicinal chemistry, 2020 - ingentaconnect.com
Triazine is the six-membered heterocyclic ring containing three nitrogens, which replace the
carbon-hydrogen unit in the benzene ring. Based on nitrogen position present in the ring …

Recent advances in quantitative structure–activity relationship models of antimalarial drugs

PK Ojha, V Kumar, J Roy, K Roy - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Due to emerging resistance to the first-line artemisinin-based antimalarials and
lack of efficient vaccines and limited chemotherapeutic alternatives, there is an urgent need …

Heterocyclic compounds bearing triazine scaffold and their biological significance: A review

T Verma, M Sinha, N Bansal - Anti-Cancer Agents in Medicinal …, 2020 - ingentaconnect.com
Benzene is a six-membered hydrocarbon ring system and if three carbon-hydrogen units of
benzene ring are replaced by nitrogen atoms then triazine is formed. Triazines are present …

Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development

L Ravindar, SA Hasbullah, KP Rakesh… - Bioorganic & Medicinal …, 2024 - Elsevier
Malaria continues to pose a significant threat to global health, which is exacerbated by the
emergence of drug-resistant strains, necessitating the urgent development of new …

A rapid, sustainable and environmental friendly protocol for the catalyst-free synthesis of 2-methyl-5-oxo-hexahydroquinoline-3-carboxylate via ultrasonic irradiation

L Devi, AR Robert, H Ganja, S Maddila… - Chemical Data …, 2020 - Elsevier
A facile, economic, highly valuable, and sustainable protocol for the synthesis of substituted
2-methyl-5-oxo-hexahydroquinoline-3-carboxylatequinolinesderivatives have been …