[HTML][HTML] ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour …
Background Cancers with a defective DNA mismatch repair (dMMR) system contain
thousands of mutations most frequently located in monomorphic microsatellites and are …
thousands of mutations most frequently located in monomorphic microsatellites and are …
Mismatch repair deficiency and response to immune checkpoint blockade
V Lee, A Murphy, DT Le, LA Diaz Jr - The oncologist, 2016 - academic.oup.com
More than 1.6 million new cases of cancer will be diagnosed in the US in 2016, resulting in
more than 500,000 deaths. Although chemotherapy has been the mainstay of treatment in …
more than 500,000 deaths. Although chemotherapy has been the mainstay of treatment in …
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer
FM Giardiello, JI Allen, JE Axilbund, CR Boland… - Gastroenterology, 2014 - Elsevier
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to
assist health care providers with the appropriate provision of genetic testing and …
assist health care providers with the appropriate provision of genetic testing and …
Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer
Lynch syndrome (LS) is an autosomal dominant inherited disorder caused by germline
mutations in DNA mismatch repair (MMR) genes. Mutation carriers are at substantially …
mutations in DNA mismatch repair (MMR) genes. Mutation carriers are at substantially …
[HTML][HTML] Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 …
Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients
With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for …
With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for …
[HTML][HTML] Multigene panel testing provides a new perspective on Lynch syndrome
CR Espenschied, H LaDuca, S Li… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Purpose Most existing literature describes Lynch syndrome (LS) as a hereditary syndrome
leading to high risks of colorectal cancer (CRC) and endometrial cancer mainly as a result of …
leading to high risks of colorectal cancer (CRC) and endometrial cancer mainly as a result of …
Low referral rate for genetic testing in racially and ethnically diverse patients despite universal colorectal cancer screening
C Muller, SM Lee, W Barge, SM Siddique… - Clinical …, 2018 - Elsevier
Background & Aims Guidelines recommend that all colorectal tumors be assessed for
mismatch repair deficiency, which could increase identification of patients with Lynch …
mismatch repair deficiency, which could increase identification of patients with Lynch …
Next-generation service delivery: a scoping review of patient outcomes associated with alternative models of genetic counseling and genetic testing for hereditary …
JM McCuaig, SR Armel, M Care, A Volenik, RH Kim… - Cancers, 2018 - mdpi.com
The combination of increased referral for genetic testing and the current shortage of genetic
counselors has necessitated the development and implementation of alternative models of …
counselors has necessitated the development and implementation of alternative models of …
Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome
T Adar, LH Rodgers, KM Shannon, M Yoshida, T Ma… - Cancer, 2018 - Wiley Online Library
BACKGROUND Lynch syndrome (LS) is the most common hereditary cause of colorectal
cancer (CRC) and endometrial cancer (EC). Screening of all CRCs for LS is currently …
cancer (CRC) and endometrial cancer (EC). Screening of all CRCs for LS is currently …
Colorectal serrated pathway cancers and precursors
MJ O'Brien, Q Zhao, S Yang - Histopathology, 2015 - Wiley Online Library
The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …