This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

Skin flaps are necessary in plastic and reconstructive surgery for the removal of skin cancer,
wounds, and ulcers. A skin flap is a portion of skin with its own blood supply that is partially …

Background The brain-stimulating agent modafinil acts through nitric oxide (NO) and
adenosine triphosphate (ATP)-sensitive potassium (K ATP) channels, involved in the skin …

Background Metformin has shown cardioprotective effects in experimental models of
ischemia reperfusion, which is partially mediated through nitric oxide (NO) synthesis. We …

PURPOSE: To evaluate the effects of copaiba oil ointment (Copaifera langsdorffii) on dorsal
skin flaps in rats. METHODS: Adult male rats (n= 30) were distributed into three groups of ten …

Chronic kidney disease (CKD) is a progressive disease with a high mortality rate and a
worldwide prevalence of 13.4%, triggered by various diseases with high incidence. The aim …

Background Random skin flaps are commonly applied during plastic surgery, but distal flap
necrosis limits their clinical applications. Valproic acid (VPA), a histone deacetylase inhibitor …

Introduction Remote ischemic preconditioning (rIPC) is a preventive strategy against
ischemia–reperfusion injury. To reduce ischemia–reperfusion injury of random-pattern skin …

Cinacalcet is a calcimimetic medicine that has been used to treat secondary
hyperparathyroidism and parathyroid cancer. Various studies have proposed the positive …

Skin flap necrosis has been remained as an unsolved problem in plastic and reconstructive
surgeries. Here, we explored the effects of metformin post-treatment on random skin flap …