[HTML][HTML] Dengue virus infection–a review of pathogenesis, vaccines, diagnosis and therapy

BH Kok, HT Lim, CP Lim, NS Lai, CY Leow, CH Leow - Virus research, 2023 - Elsevier
The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Strategies for optimization of heterologous protein expression in E. coli: Roadblocks and reinforcements

J Kaur, A Kumar, J Kaur - International journal of biological …, 2018 - Elsevier
E. coli is most preferred system used for the production of recombinant proteins in bacteria
and the availability of improved genetic tools/methods are making it more valuable than …

The emergence of phase separation as an organizing principle in bacteria

CA Azaldegui, AG Vecchiarelli, JS Biteen - Biophysical journal, 2021 - cell.com
Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …

ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

Y Pu, Y Li, X Jin, T Tian, Q Ma, Z Zhao, S Lin, Z Chen… - Molecular cell, 2019 - cell.com
Cell dormancy is a widespread mechanism used by bacteria to evade environmental
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …

Complete biosynthesis of noscapine and halogenated alkaloids in yeast

Y Li, S Li, K Thodey, I Trenchard… - Proceedings of the …, 2018 - National Acad Sciences
Microbial biosynthesis of plant natural products from simple building blocks is a promising
approach toward scalable production and modification of high-value compounds. The …

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

KD Brune, DB Leneghan, IJ Brian, AS Ishizuka… - Scientific reports, 2016 - nature.com
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …

The CamSol method of rational design of protein mutants with enhanced solubility

P Sormanni, FA Aprile, M Vendruscolo - Journal of molecular biology, 2015 - Elsevier
Protein solubility is often an essential requirement in biotechnological and biomedical
applications. Great advances in understanding the principles that determine this specific …

Programmable polyproteams built using twin peptide superglues

G Veggiani, T Nakamura, MD Brenner… - Proceedings of the …, 2016 - National Acad Sciences
Programmed connection of amino acids or nucleotides into chains introduced a revolution in
control of biological function. Reacting proteins together is more complex because of the …

Plants as sources of natural and recombinant anti-cancer agents

JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …

[HTML][HTML] Bioengineering bacterial outer membrane vesicles as vaccine platform

MJH Gerritzen, DE Martens, RH Wijffels… - Biotechnology …, 2017 - Elsevier
Outer membrane vesicles (OMVs) are naturally non-replicating, highly immunogenic
spherical nanoparticles derived from Gram-negative bacteria. OMVs from pathogenic …