Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles

M Mahmoudi, H Hofmann… - Chemical …, 2012 - ACS Publications
Nanotechnology has become a key word of public interest, since people realized the social
and economic power of nanotechnology development. Nanotechnology has already …

A review of the clinical implications of anti-infective biomaterials and infection-resistant surfaces

D Campoccia, L Montanaro, CR Arciola - Biomaterials, 2013 - Elsevier
Infection is currently regarded as the most severe and devastating complication associated
to the use of biomaterials. The important social, clinical and economic impacts of implant …

Single-chain polymer nanoparticles

MK Aiertza, I Odriozola, G Cabañero… - Cellular and Molecular …, 2012 - Springer
The synthesis of polymer nanoparticles (NPs) with controlled characteristics has become an
appealing research topic lately. Nanomedicine, and especially drug delivery and imaging …

Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis

JL Arias, JD Unciti-Broceta, J Maceira… - Journal of Controlled …, 2015 - Elsevier
Targeted delivery of therapeutics is an alternative approach for the selective treatment of
infectious diseases. The surface of African trypanosomes, the causative agents of African …

Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems

AC de Jesus Oliveira, LL Chaves, FOS Ribeiro… - Carbohydrate …, 2021 - Elsevier
Chemical modification of polysaccharides is an important approach for their transformation
into customized matrices that suit different applications. Microwave irradiation (MW) has …

Therapeutical approaches under investigation for treatment of Chagas disease

MT Bahia, LF Diniz, VCF Mosqueira - Expert opinion on …, 2014 - Taylor & Francis
Introduction: A century after its discovery, American trypanosomiasis or Chagas disease
remains a serious health problem in Latin America, where it affects around 7–8 million …

Nanomedicines against Chagas disease: an update on therapeutics, prophylaxis and diagnosis

MJ Morilla, EL Romero - Nanomedicine, 2015 - Taylor & Francis
Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma
cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic …

Solid nanomedicines of nifurtimox and benznidazole for the oral treatment of chagas disease

M Rolon, E Hanna, C Vega, C Coronel… - Pharmaceutics, 2022 - mdpi.com
Chagas disease (CD) is a parasitic zoonosis endemic in Central and South America
affecting nearly 10 million people, with 100 million people at high risk of contracting the …

Curcumin treatment provides protection against Trypanosoma cruzi infection

F Nagajyothi, D Zhao, LM Weiss, HB Tanowitz - Parasitology research, 2012 - Springer
Trypanosoma cruzi, the etiologic agent of Chagas disease, causes an acute myocarditis and
chronic cardiomyopathy. The current therapeutic agents for this disease are not always …

Poly-epsilon-caprolactone nanoparticles enhance ursolic acid in vivo efficacy against Trypanosoma cruzi infection

JP Abriata, JO Eloy, TB Riul, PM Campos… - Materials Science and …, 2017 - Elsevier
Despite affecting millions of people worldwide, Chagas disease is still neglected by the
academia and industry and the therapeutic option available, benznidazole, presents limited …