Toxoplasma gondii infection: novel emerging therapeutic targets

J Müller, A Hemphill - Expert opinion on therapeutic targets, 2023 - Taylor & Francis
Introduction Toxoplasmosis constitutes a challenge for public health, animal production, and
welfare. So far, only a limited panel of drugs has been marketed for clinical applications. In …

The Toxoplasma plant‐like vacuolar compartment (PLVAC)

AJ Stasic, SNJ Moreno… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of
congenital disease and infection in immunocompromised patients. T. gondii shares several …

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

G Gorfu, KM Cirelli, MB Melo, K Mayer-Barber… - MBio, 2014 - Am Soc Microbiol
Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent
on the activation of the innate immune response. In this study, we investigated the role of …

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

KM Cirelli, G Gorfu, MA Hassan, M Printz… - PLoS …, 2014 - journals.plos.org
Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded
species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring …

Toxoplasma gondii ingests and digests host cytosolic proteins

Z Dou, OL McGovern, M Di Cristina, VB Carruthers - MBio, 2014 - Am Soc Microbiol
The protozoan parasite Toxoplasma gondii resides within a nonfusogenic vacuole during
intracellular replication. Although the limiting membrane of this vacuole provides a protective …

Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease

NA Botwright, AR Mohamed, J Slinger… - Frontiers in …, 2021 - frontiersin.org
Marine farmed Atlantic salmon (Salmo salar) are susceptible to recurrent amoebic gill
disease (AGD) caused by the ectoparasite Neoparamoeba perurans over the growout …

Protection via a ROM4 DNA vaccine and peptide against Toxoplasma gondii in BALB/c mice

Y Han, A Zhou, G Lu, G Zhao, L Wang, J Guo… - BMC Infectious …, 2017 - Springer
Background Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite
with a broad host range including most warm-blooded animals, including humans. T. gondii …

The Mitochondrial Genome and a 60‐kb Nuclear DNA Segment from Naegleria fowleri, the Causative Agent of Primary Amoebic Meningoencephalitis

EK Herman, AL Greninger… - Journal of Eukaryotic …, 2013 - Wiley Online Library
N aegleria fowleri is a unicellular eukaryote causing primary amoebic meningoencephalitis,
a neuropathic disease killing 99% of those infected, usually within 7–14 days. Naegleria …

Identification and characterization of Toxoplasma gondii aspartic protease 1 as a novel vaccine candidate against toxoplasmosis

G Zhao, A Zhou, G Lu, M Meng, M Sun, Y Bai, Y Han… - Parasites & vectors, 2013 - Springer
Background Toxoplasma gondii is an obligate intracellular parasite that can pose a serious
threat to human health by causing toxoplasmosis. There are no drugs that target the chronic …

Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis

G Zhao, A Zhou, G Lv, M Meng, M Sun, Y Bai… - BMC infectious …, 2013 - Springer
Background Toxoplasma gondii, an obligate intracellular apicomplexan parasite, infects a
wide range of warm-blooded animals including humans. T. gondii expresses five members …