In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …

Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Hypermethylation of CpG islands is a phenomenon commonly observed during the
development and progression of human tumors. Detection of methylated-CpG islands in …

The Wnt (wingless-type) signaling pathway plays an important role in embryonic
development, tissue homeostasis, and tumor progression becaluse of its effect on cell …