LIGHT-SABRE Hyperpolarizes 1-13C-Pyruvate Continuously without Magnetic Field Cycling

AN Pravdivtsev, K Buckenmaier, N Kempf… - The Journal of …, 2023 - ACS Publications
Nuclear spin hyperpolarization enables real-time observation of metabolism and
intermolecular interactions in vivo. 1-13C-pyruvate is the leading hyperpolarized tracer …

Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT

AB Schmidt, J Eills, L Dagys, M Gierse… - The Journal of …, 2023 - ACS Publications
Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …

Robust parahydrogen-induced polarization at high concentrations

L Dagys, MC Korzeczek, AJ Parker, J Eills… - Science …, 2024 - science.org
Parahydrogen-induced polarization (PHIP) is a potent technique for generating target
molecules with high nuclear spin polarization. The PHIP process involves a chemical …

Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation

F Ellermann, A Sirbu, A Brahms, C Assaf… - Nature …, 2023 - nature.com
Nuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic
resonance signal by several orders of magnitude and has enabled real-time metabolic …

Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer

K Mouloudakis, S Bodenstedt, M Azagra… - The Journal of …, 2023 - ACS Publications
We introduce a method for nondestructive quantification of nuclear spin polarization, of
relevance to hyperpolarized spin tracers widely used in magnetic resonance from …

J Coupling Constants of <1 Hz Enable 13C Hyperpolarization of Pyruvate via Reversible Exchange of Parahydrogen

CD Assaf, X Gui, AA Auer, SB Duckett… - The Journal of …, 2024 - ACS Publications
Observing pyruvate metabolism in vivo has become a focal point of molecular magnetic
resonance imaging. Signal amplification by reversible exchange (SABRE) has recently …

Adiabatic passage through level anticrossings in systems of chemically inequivalent protons incorporating parahydrogen: theory, experiment, and prospective …

MJ Ferrer, EL Kuker, E Semenova… - Journal of the …, 2022 - ACS Publications
Level anticrossings (LACs) are ubiquitous in quantum systems and have been exploited for
spin-order transfer in hyperpolarized nuclear magnetic resonance spectroscopy. This paper …

Protecting quantum information via destructive interference of correlated noise

A Salhov, Q Cao, J Cai, A Retzker, F Jelezko… - Physical Review Letters, 2024 - APS
Decoherence and imperfect control are crucial challenges for quantum technologies.
Common protection strategies rely on noise temporal autocorrelation, which is not optimal if …

Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

L Nagel, M Gierse, W Gottwald, Z Ahmadova… - Advanced …, 2023 - Wiley Online Library
Hyperpolarization techniques increase nuclear spin polarization by more than four orders of
magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value …

Diamond quantum sensors in microfluidics technology

M Fujiwara - Biomicrofluidics, 2023 - pubs.aip.org
Diamond quantum sensing is an emerging technology for probing multiple physico-chemical
parameters in the nano-to micro-scale dimensions within diverse chemical and biological …