Oxidative stress in MeHg-induced neurotoxicity

M Farina, M Aschner, JBT Rocha - Toxicology and applied pharmacology, 2011 - Elsevier
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017 - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

[HTML][HTML] Diphenyl diselenide a janus-faced molecule

CW Nogueira, JBT Rocha - Journal of the Brazilian Chemical Society, 2010 - SciELO Brasil
In this review, we summarized the potential role of synthetic organoseleno compounds as
therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the …

Oxidative stress in methylmercury-induced cell toxicity

A Antunes dos Santos, B Ferrer, F Marques Gonçalves… - Toxics, 2018 - mdpi.com
Methylmercury (MeHg) is a hazardous environmental pollutant, which elicits significant
toxicity in humans. The accumulation of MeHg through the daily consumption of large …

The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats

AE Abdel Moneim - Metabolic brain disease, 2015 - Springer
The central nervous system is one of the most vulnerable organs affected by mercury
toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of …

Guanosine and its role in neuropathologies

LEB Bettio, J Gil-Mohapel, ALS Rodrigues - Purinergic signalling, 2016 - Springer
Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

Breast cancer expresses functional NMDA receptors

WG North, G Gao, VA Memoli, RH Pang… - Breast cancer research …, 2010 - Springer
We demonstrate here that functional NMDAR1 and NMDAR2 receptors are expressed by
Mcf-7 and SKBR3 breast cancer cell lines, and possibly by most or all high-grade breast …

Chemical speciation of selenium and mercury as determinant of their neurotoxicity

CS Oliveira, BC Piccoli, M Aschner, JBT Rocha - Neurotoxicity of metals, 2017 - Springer
The antagonism of mercury toxicity by selenium has been well documented. Mercury is a
toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or …

Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen

Z Yin, E Lee, M Ni, H Jiang, D Milatovic, L Rongzhu… - Neurotoxicology, 2011 - Elsevier
Methylmercury (MeHg) preferentially accumulates in glia of the central nervous system
(CNS), but its toxic mechanisms have yet to be fully recognized. In the present study, we …

Intestinal microbiota protects against methylmercury-induced neurotoxicity

T Ke, A Rajoo, AA Tinkov, AV Skalny, Y Tizabi… - Biometals, 2024 - Springer
Methylmercury (MeHg) remains a global public health issue because of its frequent
presence in human food sources obtained from the water. The excretion of MeHg in humans …