Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against
multidrug‐resistant Plasmodium. The drug is used in combination with artesunate for the …

Elucidation of the energetic principles of binding affinity and specificity is a central task in
many branches of current sciences: biology, medicine, pharmacology, chemistry, material …

The interaction of two natural protoberberine alkaloids berberine and palmatine and the
synthetic derivative coralyne with the RNA triplex poly (U). poly (A)* poly (U) was studied …

In mammalian cells, the second messenger (2′–5′, 3′–5′) cyclic guanosine
monophosphate-adenosine monophosphate (2′, 3′-cGAMP), is produced by the cytosolic …

Quinacrine (Qx), a molecule used as an antimalarial, has shown anticancer, antiprion, and
antiviral activity. The most relevant antiviral activities of Qx are related to its ability to raise pH …

In this study absorbance, fluorescence, circular dichroic spectroscopy, viscosity, thermal
melting and calorimetric techniques were employed to understand the binding of the …

Background Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to
the RNA triplex poly (U)• poly (A)* poly (U) was studied by various biophysical techniques …

The standard drug discovery paradigm of single molecule–single biological target–single
biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is …

The interaction of the natural benzophenanthridine alkaloid chelerythrine with DNA was
studied by spectroscopy, viscometry and calorimetry techniques. The absorbance and …

The T box transcription antitermination system is a riboswitch found primarily in Gram-
positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a …