Reactive oxygen species‐regulating strategies based on nanomaterials for disease treatment
Reactive oxygen species (ROS) play an essential role in physiological and pathological
processes. Studies on the regulation of ROS for disease treatments have caused wide …
processes. Studies on the regulation of ROS for disease treatments have caused wide …
The blood–spinal cord barrier: morphology and clinical implications
V Bartanusz, D Jezova, B Alajajian… - Annals of …, 2011 - Wiley Online Library
The blood–spinal cord barrier (BSCB) is the functional equivalent of the blood–brain barrier
(BBB) in the sense of providing a specialized microenvironment for the cellular constituents …
(BBB) in the sense of providing a specialized microenvironment for the cellular constituents …
Industrial applications of immobilized nano-biocatalysts
Immobilized enzyme-based catalytic constructs could greatly improve various industrial
processes due to their extraordinary catalytic activity and reaction specificity. In recent …
processes due to their extraordinary catalytic activity and reaction specificity. In recent …
Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury
X Yun, VD Maximov, J Yu… - Journal of Cerebral …, 2013 - journals.sagepub.com
Stroke is one of the major causes of death and disability in the United States. After cerebral
ischemia and reperfusion injury, the generation of reactive oxygen species (ROS) and …
ischemia and reperfusion injury, the generation of reactive oxygen species (ROS) and …
Agile delivery of protein therapeutics to CNS
X Yi, DS Manickam, A Brynskikh… - Journal of Controlled …, 2014 - Elsevier
A variety of therapeutic proteins have shown potential to treat central nervous system (CNS)
disorders. Challenge to deliver these protein molecules to the brain is well known. Proteins …
disorders. Challenge to deliver these protein molecules to the brain is well known. Proteins …
BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS
The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …
the urgent development of efficient drugs. While many of these medicines are already …
Antioxidant activity of SOD and catalase conjugated with nanocrystalline ceria
Interactions of nanoparticles with biological matter—both somatically and in nature—draw
scientists' attention. Nanoparticulate systems are believed to be our saviors, acting as …
scientists' attention. Nanoparticulate systems are believed to be our saviors, acting as …
Nanomedicine for treating spinal cord injury
Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult
rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both …
rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both …
Conjugates of superoxide dismutase 1 with amphiphilic poly (2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in …
Superoxide dismutase 1 (SOD1) efficiently catalyzes dismutation of superoxide, but its poor
delivery to the target sites in the body, such as brain, hinders its use as a therapeutic agent …
delivery to the target sites in the body, such as brain, hinders its use as a therapeutic agent …
Current options for drug delivery to the spinal cord
Introduction: Spinal cord disorders (SCDs) are among the most devastating neurological
diseases, due to their acute and long-term health consequences, the reduced quality of life …
diseases, due to their acute and long-term health consequences, the reduced quality of life …