Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-
predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA …

The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic
and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD). FXR is …

Bile acids (BAs) are the central signals in enterohepatic communication, and they also
integrate microbiota-derived signals into enterohepatic signaling. The tissue distribution and …

Abstract Background and Aims Chronic diarrhea affects about 5% of the population overall.
Altered bile acid metabolism is a common but frequently undiagnosed cause. Methods We …

Discovered 20 years ago, fibroblast growth factor (FGF) 19, and its mouse ortholog FGF15,
were the first members of a new subfamily of FGFs able to act as hormones. During fetal life …

Objective There are altered mucosal functions in irritable bowel syndrome with diarrhoea
(IBS-D);~ 30% of patients with IBS-D have abnormal bile acid (BA) metabolism (ABAM) and …