Bone substitutes are used in nearly half of all musculoskeletal surgeries. The “gold
standard” graft is an autograft that is limited by supply and site morbidity. Therefore, allograft …

Bone marrow stromal cells (BMSCs) and periosteum-derived cells (PDCs) represent
promising skeletal stem cell sources to treat critical-size bone defects. However, the large …

While tissue engineering holds significant potential to address current limitations in
reconstructive surgery of the head and neck, few constructs have made their way into routine …

Bone defects caused by cancer surgery or trauma have a strong negative impact on human
health. Treatment with cell and material-based complexes provides an alternative strategy …

Background Bone defects lead to dramatic changes in the quality of life. Acellular dermal
matrix (ADM) and decellularized bone matrix (DBM) are natural scaffolds for tissue …