Biomarkers as prognostic predictors and therapeutic guide in critically ill patients: clinical evidence

R Méndez Hernández, F Ramasco Rueda - Journal of Personalized …, 2023 - mdpi.com
A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Biomarkers of inflammation and the etiology of sepsis

I Grondman, A Pirvu, A Riza, M Ioana… - Biochemical Society …, 2020 - portlandpress.com
Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia

DO Thomas-Rüddel, B Poidinger, M Kott, M Weiss… - Critical care, 2018 - Springer
Background This study aimed to evaluate the accuracy of procalcitonin (PCT) serum
concentrations to diagnose Gram-negative bacteremia and the association of PCT serum …

Sepsis: current definition, pathophysiology, diagnosis, and management

AM Taeb, MH Hooper, PE Marik - Nutrition in Clinical Practice, 2017 - Wiley Online Library
Sepsis is a clinical syndrome that results from the dysregulated inflammatory response to
infection that leads to organ dysfunction. The resulting losses to society in terms of financial …

[HTML][HTML] Procalcitonin levels in bloodstream infections caused by different sources and species of bacteria

ST Yan, LC Sun, HB Jia, W Gao, JP Yang… - The American journal of …, 2017 - Elsevier
Objective The aim of this study was to evaluate procalcitonin (PCT) diagnostic accuracy in
discriminating gram-negative (GN) from gram-positive (GP) bloodstream infections and …

A new treatment approach: Melatonin and ascorbic acid synergy shields against sepsis-induced heart and kidney damage in male rats

H Üstündağ, S Doğanay, FD Kalındemirtaş, Ö Demir… - Life Sciences, 2023 - Elsevier
Aim To investigate the combined therapeutic potential of melatonin and ascorbic acid in
mitigating sepsis-induced heart and kidney injury in male rats and assess the combination …

Septic encephalopathy in the elderly–biomarkers of potential clinical utility

S Schütze, DA Drevets, SC Tauber… - Frontiers in Cellular …, 2023 - frontiersin.org
Next to acute sickness behavior, septic encephalopathy is the most frequent involvement of
the brain during infection. It is characterized by a cross-talk of pro-inflammatory cells across …

Serum procalcitonin levels distinguish Gram-negative bacterial sepsis from Gram-positive bacterial and fungal sepsis

S Li, H Rong, Q Guo, Y Chen, G Zhang… - Journal of research in …, 2016 - journals.lww.com
Background: Serum procalcitonin (PCT) levels differ in patients with bacterial or fungal
infections and are significantly elevated in patients with Gram-negative bacteremia. We …

Reliability of admission procalcitonin testing for capturing bacteremia across the sepsis spectrum: real-world utilization and performance characteristics, 65 US …

A Lawandi, M Oshiro, S Warner, G Diao… - Critical care …, 2023 - journals.lww.com
OBJECTIVES: Serum procalcitonin is often ordered at admission for patients with suspected
sepsis and bloodstream infections (BSIs), although its performance characteristics in this …

Staphylococcus aureus pneumonia in the community

H He, RG Wunderink - Seminars in respiratory and critical care …, 2020 - thieme-connect.com
Staphylococcus aureus is an emergent etiology of community-acquired pneumonia (CAP)
over the past 2 decades, with severe community-acquired pneumonia (SCAP) caused by …