Late-stage carbon-14 labeling and isotope exchange: emerging opportunities and future challenges
V Babin, F Taran, D Audisio - JACS Au, 2022 - ACS Publications
Carbon-14 (14C) is a gold standard technology routinely utilized in pharmaceutical and
agrochemical industries for tracking synthetic organic molecules and providing their …
agrochemical industries for tracking synthetic organic molecules and providing their …
Recent Advances in Nickel Catalyzed Carbonylative Reactions via the Insertion of Carbon Monoxide†
X Chen, G Chen, Z Lian - Chinese Journal of Chemistry, 2024 - Wiley Online Library
Comprehensive Summary Carbonyl compounds have attracted considerable attention due
to their extensive applications in drug discovery. Furthermore, they are important synthetic …
to their extensive applications in drug discovery. Furthermore, they are important synthetic …
Nickel‐Catalyzed Asymmetric Hydroaryloxy‐and Hydroalkoxycarbonylation of Cyclopropenes
R Yu, SZ Cai, C Li, X Fang - Angewandte Chemie International …, 2022 - Wiley Online Library
The asymmetric Reppe carbonylation reactions provide a straightforward access to α‐chiral
carbonyl compounds. The reported paradigms predominantly adopted precious palladium …
carbonyl compounds. The reported paradigms predominantly adopted precious palladium …
Nickel-catalyzed acylzincation of allenes with organozincs and CO
X Wu, C Wang, N Liu, J Qu, Y Chen - Nature Communications, 2023 - nature.com
Transition metal-catalyzed carbonylative reaction with CO gas are among the central task in
organic synthesis, enabling the construction of highly valuable carbonyl compound. Here …
organic synthesis, enabling the construction of highly valuable carbonyl compound. Here …
Fast carbon isotope exchange of carboxylic acids enabled by organic photoredox catalysis
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange
of C (sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal …
of C (sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal …
Nickel-Catalyzed Highly Selective Reductive Carbonylation Using Oxalyl Chloride as the Carbonyl Source
J Wang, Y Yin, X He, QL Duan, R Bai, HW Shi… - ACS …, 2023 - ACS Publications
Nickel-catalyzed carbonylative cross-electrophile coupling which emerges as a powerful,
efficient, and low-cost method for constructing challenging carbonyl derivatives has attracted …
efficient, and low-cost method for constructing challenging carbonyl derivatives has attracted …
Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas
Y Zhang, Q Cao, Y Xi, X Wu, J Qu… - Journal of the American …, 2024 - ACS Publications
We describe a nickel-catalyzed carbonylative cross-coupling of unactivated secondary alkyl
electrophiles with the organozinc reagent at atmospheric CO gas, thus allowing the …
electrophiles with the organozinc reagent at atmospheric CO gas, thus allowing the …
Nickel-catalyzed deaminative Sonogashira coupling of alkylpyridinium salts enabled by NN2 pincer ligand
X Zhang, D Qi, C Jiao, X Liu, G Zhang - Nature Communications, 2021 - nature.com
Alkynes are amongst the most valuable functional groups in organic chemistry and widely
used in chemical biology, pharmacy, and materials science. However, the preparation of …
used in chemical biology, pharmacy, and materials science. However, the preparation of …
Nickel-mediated alkoxycarbonylation for complete carbon isotope replacement
Many commercial drugs, as well as upcoming pharmaceutically active compounds in the
pipeline, display aliphatic carboxylic acids or derivatives thereof as key structural entities …
pipeline, display aliphatic carboxylic acids or derivatives thereof as key structural entities …
Nickel-catalyzed alkoxycarbonylation of aryl iodides with 1 atm CO
N Liu, X Wu, C Wang, J Qu, Y Chen - Chemical Communications, 2022 - pubs.rsc.org
A nickel-catalyzed alkoxycarbonylation of aromatic iodides with alcohols under atmospheric
pressure of carbon monoxide is presented here. This operationally simple protocol allows …
pressure of carbon monoxide is presented here. This operationally simple protocol allows …