Late-stage carbon-14 labeling and isotope exchange: emerging opportunities and future challenges

V Babin, F Taran, D Audisio - JACS Au, 2022 - ACS Publications
Carbon-14 (14C) is a gold standard technology routinely utilized in pharmaceutical and
agrochemical industries for tracking synthetic organic molecules and providing their …

Recent Advances in Nickel Catalyzed Carbonylative Reactions via the Insertion of Carbon Monoxide

X Chen, G Chen, Z Lian - Chinese Journal of Chemistry, 2024 - Wiley Online Library
Comprehensive Summary Carbonyl compounds have attracted considerable attention due
to their extensive applications in drug discovery. Furthermore, they are important synthetic …

Nickel‐Catalyzed Asymmetric Hydroaryloxy‐and Hydroalkoxycarbonylation of Cyclopropenes

R Yu, SZ Cai, C Li, X Fang - Angewandte Chemie International …, 2022 - Wiley Online Library
The asymmetric Reppe carbonylation reactions provide a straightforward access to α‐chiral
carbonyl compounds. The reported paradigms predominantly adopted precious palladium …

Nickel-catalyzed acylzincation of allenes with organozincs and CO

X Wu, C Wang, N Liu, J Qu, Y Chen - Nature Communications, 2023 - nature.com
Transition metal-catalyzed carbonylative reaction with CO gas are among the central task in
organic synthesis, enabling the construction of highly valuable carbonyl compound. Here …

Fast carbon isotope exchange of carboxylic acids enabled by organic photoredox catalysis

D Kong, M Munch, Q Qiqige, CJC Cooze… - Journal of the …, 2021 - ACS Publications
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange
of C (sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal …

Nickel-Catalyzed Highly Selective Reductive Carbonylation Using Oxalyl Chloride as the Carbonyl Source

J Wang, Y Yin, X He, QL Duan, R Bai, HW Shi… - ACS …, 2023 - ACS Publications
Nickel-catalyzed carbonylative cross-electrophile coupling which emerges as a powerful,
efficient, and low-cost method for constructing challenging carbonyl derivatives has attracted …

Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas

Y Zhang, Q Cao, Y Xi, X Wu, J Qu… - Journal of the American …, 2024 - ACS Publications
We describe a nickel-catalyzed carbonylative cross-coupling of unactivated secondary alkyl
electrophiles with the organozinc reagent at atmospheric CO gas, thus allowing the …

Nickel-catalyzed deaminative Sonogashira coupling of alkylpyridinium salts enabled by NN2 pincer ligand

X Zhang, D Qi, C Jiao, X Liu, G Zhang - Nature Communications, 2021 - nature.com
Alkynes are amongst the most valuable functional groups in organic chemistry and widely
used in chemical biology, pharmacy, and materials science. However, the preparation of …

Nickel-mediated alkoxycarbonylation for complete carbon isotope replacement

SJ Ton, KT Neumann, P Nørby… - Journal of the American …, 2021 - ACS Publications
Many commercial drugs, as well as upcoming pharmaceutically active compounds in the
pipeline, display aliphatic carboxylic acids or derivatives thereof as key structural entities …

Nickel-catalyzed alkoxycarbonylation of aryl iodides with 1 atm CO

N Liu, X Wu, C Wang, J Qu, Y Chen - Chemical Communications, 2022 - pubs.rsc.org
A nickel-catalyzed alkoxycarbonylation of aromatic iodides with alcohols under atmospheric
pressure of carbon monoxide is presented here. This operationally simple protocol allows …