TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature
The transient receptor potential superfamily of ion channels (TRP channels) is widely
recognized for the roles its members play in sensory nervous systems. However, the …
recognized for the roles its members play in sensory nervous systems. However, the …
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …
[HTML][HTML] A structural overview of the ion channels of the TRPM family
The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP
cation channels. The TRPM subfamily is composed of eight members that are involved in …
cation channels. The TRPM subfamily is composed of eight members that are involved in …
Ligand binding at the protein–lipid interface: strategic considerations for drug design
J Payandeh, M Volgraf - Nature Reviews Drug Discovery, 2021 - nature.com
Many drug targets are embedded within the phospholipid bilayer of cellular membranes,
including G protein-coupled receptors, ion channels, transporters and membrane-bound …
including G protein-coupled receptors, ion channels, transporters and membrane-bound …
Structural and functional analyses of a GPCR-inhibited ion channel TRPM3
C Zhao, R MacKinnon - Neuron, 2023 - cell.com
G-protein coupled receptors (GPCRs) govern the physiological response to stimuli by
modulating the activity of downstream effectors, including ion channels. TRPM3 is an ion …
modulating the activity of downstream effectors, including ion channels. TRPM3 is an ion …
Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A
BH Lee, JJ De Jesús Pérez, V Moiseenkova-Bell… - Nature …, 2023 - nature.com
Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …
important cellular regulatory roles, including activation and inhibition of ion channels. The …
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular
transducer responsible for the cool sensation elicited by menthol and cold in mammals …
transducer responsible for the cool sensation elicited by menthol and cold in mammals …
Structural insights into TRPM8 inhibition and desensitization
MM Diver, Y Cheng, D Julius - Science, 2019 - science.org
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of
environmental cold and an important target for treating pathological cold hypersensitivity …
environmental cold and an important target for treating pathological cold hypersensitivity …
Mechanism of praziquantel action at a parasitic flatworm ion channel
SK Park, L Friedrich, NA Yahya, CM Rohr… - Science translational …, 2021 - science.org
Praziquantel (PZQ) is an essential medicine for treating parasitic flatworm infections such as
schistosomiasis, which afflicts over 250 million people. However, PZQ is not universally …
schistosomiasis, which afflicts over 250 million people. However, PZQ is not universally …