[HTML][HTML] A critical review of histopathological findings associated with endocrine and non-endocrine hepatic toxicity in fish models

JC Wolf, JR Wheeler - Aquatic Toxicology, 2018 - Elsevier
Although frequently examined as a target organ for non-endocrine toxicity, histopathological
evaluation of the liver is becoming a routine component of endocrine disruption studies that …

The necessity of a global binding framework for sustainable management of chemicals and materials—interactions with climate and biodiversity

KG Steinhäuser, A Von Gleich, M Große Ophoff… - Sustainable …, 2022 - mdpi.com
Sustainable chemicals and materials management deals with both the risks and the
opportunities of chemicals and products. It is not only focused on hazards and risks of …

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

D Knapen, E Stinckens, JE Cavallin… - Environmental …, 2020 - ACS Publications
A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …

[HTML][HTML] Diet and food type affect urinary pesticide residue excretion profiles in healthy individuals: results of a randomized controlled dietary intervention trial

L Rempelos, J Wang, M Barański, A Watson… - The American journal of …, 2022 - Elsevier
Background Observational studies have linked pesticide exposure to various diseases,
whereas organic food consumption has been associated with positive health outcomes …

A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β‐trenbolone

GT Ankley, KK Coady, M Gross… - Environmental …, 2018 - Wiley Online Library
Trenbolone acetate is widely used in some parts of the world for its desirable anabolic
effects on livestock. Several metabolites of the acetate, including 17β‐trenbolone, have …

[HTML][HTML] Combined toxicity of therapeutic pharmaceuticals to duckweed, Lemna minor

M Markovic, PA Neale, B Nidumolu, A Kumar - … and environmental safety, 2021 - Elsevier
Pharmaceuticals, which are designed to be biologically active at low concentrations, are
found in surface waters, meaning aquatic organisms can be exposed to complex mixtures of …

AOP Report: adverse outcome pathways for aromatase inhibition or androgen receptor agonism leading to male‐biased sex ratio and population decline in fish

GT Ankley, K Santana‐Rodriguez… - Environmental …, 2023 - Wiley Online Library
Screening and testing of potential endocrine‐disrupting chemicals for ecological effects are
examples of risk assessment/regulatory activities that can employ adverse outcome …

Critical review of read‐across potential in testing for endocrine‐related effects in vertebrate ecological receptors

ME McArdle, EL Freeman, JP Staveley… - Environmental …, 2020 - Wiley Online Library
Recent regulatory testing programs have been designed to evaluate whether a chemical
has the potential to interact with the endocrine system and could cause adverse effects …

Thresholds of adversity and their applicability to endocrine disrupting chemicals

S Brescia - Critical reviews in toxicology, 2020 - Taylor & Francis
Abstract Within the European Union, various legislative acts contain specific provisions on
endocrine disruption, requiring the regulation of substances with endocrine disrupting …

Secondary treatment phase of tertiary wastewater treatment works significantly reduces estrogenic load

R Islam, RMK Yu, M Andrew-Priestley, N Smith… - Water Research, 2021 - Elsevier
Estrogenic compounds enter waterways via effluents from wastewater treatment works
(WWTW), thereby indicating a potential risk to organisms inhabiting adjacent receiving …