Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury

ME Huibregtse, JJ Bazarian, SR Shultz… - … & Biobehavioral Reviews, 2021 - Elsevier
Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …

Disease-and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory …

T Aczél, B Benczik, B Ágg, T Körtési, P Urbán… - The Journal of …, 2022 - Springer
Background Migraine is a primary headache with genetic susceptibility, but the
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …

Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

Y Xiong, A Mahmood, M Chopp - Neural Regeneration Research, 2024 - journals.lww.com
Traumatic brain injury is a serious and complex neurological condition that affects millions of
people worldwide. Despite significant advancements in the field of medicine, effective …

Cell-derived exosomes as therapeutic strategies and exosome-derived microRNAs as biomarkers for traumatic brain injury

J Wang, J Wang, X Li, K Shu - Journal of Clinical Medicine, 2022 - mdpi.com
Traumatic brain injury (TBI) is a complex, life-threatening condition that causes mortality and
disability worldwide. No effective treatment has been clinically verified to date. Achieving …

Extracellular vesicle proteins and micrornas are linked to chronic post-traumatic stress disorder symptoms in service members and veterans with mild traumatic brain …

VA Guedes, C Lai, C Devoto, KA Edwards… - Frontiers in …, 2021 - frontiersin.org
Symptoms of post-traumatic stress disorder (PTSD) are common in military populations, and
frequently associated with a history of combat-related mild traumatic brain injury (mTBI). In …

Clinical research findings from the long-term impact of military-relevant brain injury consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) 2013 …

DX Cifu - Brain injury, 2022 - Taylor & Francis
This is a summary of the published research from the 14 observational, longitudinal and big-
data, epidemiological studies supported by the LIMBIC-CENC program from 2013–2021 …

Using bioinformatics technology to mine the expression of serum exosomal miRNA in patients with traumatic brain injury

X Huang, X Xu, C Wang, Y Wang, Y Yang… - Frontiers in …, 2023 - frontiersin.org
Introduction Traumatic brain injury (TBI) is considered the most common traumatic
neurological disease, is associated with high mortality and long-term complications, and is a …

Bidirectional brain-systemic interactions and outcomes after TBI

AI Faden, JP Barrett, BA Stoica, RJ Henry - Trends in neurosciences, 2021 - cell.com
Traumatic brain injury (TBI) is a debilitating disorder associated with chronic progressive
neurodegeneration and long-term neurological decline. Importantly, there is now substantial …

[HTML][HTML] Extracellular vesicles: The next generation of biomarkers and treatment for central nervous system diseases

G Zanirati, PG Dos Santos, AM Alcará, F Bruzzo… - International Journal of …, 2024 - mdpi.com
It has been widely established that the characterization of extracellular vesicles (EVs),
particularly small EVs (sEVs), shed by different cell types into biofluids, helps to identify …