[HTML][HTML] An overview of recent advances in duplex DNA recognition by small molecules
As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …
ligands during the cell cycle, and is amenable to such intervention in diseases such as …
Antineoplastic DNA-binding compounds: Intercalating and minor groove binding drugs
K Mišković, M Bujak, M Baus Lončar… - Arhiv za higijenu rada i …, 2013 - hrcak.srce.hr
Sažetak DNA intercalating and minor groove binding compounds are new weapons in the
battle against malignant diseases. These antineoplastic agents target the DNA molecule …
battle against malignant diseases. These antineoplastic agents target the DNA molecule …
From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy
The myotonic dystrophies (DM) are human diseases in which the accumulation of toxic RNA
(CUG or CCUG) repeats in the cell causes sequestration of splicing factors, including …
(CUG or CCUG) repeats in the cell causes sequestration of splicing factors, including …
Facile synthesis of acridines via Pd (0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol
TJ Wang, WW Chen, Y Li, MH Xu - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
A facile and efficient approach for the synthesis of a variety of acridines via the tandem
coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The …
coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The …
Synthesis of Benzoacridines and Benzophenanthridines by Regioselective Pd‐Catalyzed Cross‐Coupling Reactions Followed by Acid‐Mediated Cycloisomerizations
S Janke, S Boldt, K Ghazargan, P Ehlers… - European Journal of …, 2019 - Wiley Online Library
A convenient synthesis of various benzoacridines and benzophenanthridines from readily
available dihalogenated quinolines is reported. The synthesis is based on regioselective …
available dihalogenated quinolines is reported. The synthesis is based on regioselective …
YM155 inhibits topoisomerase function
YM155 (sepantronium bromide) has been evaluated in clinical trials as a survivin
suppressant, but despite positive signals from early work, later studies were negative …
suppressant, but despite positive signals from early work, later studies were negative …
Pd (II)-catalyzed one-pot, three-step route for the synthesis of unsymmetrical acridines
Unsymmetric acridines are synthesized via a one-pot amination/cyclization/aromatization
reaction for the first time. With Pd (OAc) 2-X-Phos as the catalyst, a series of unsymmetric …
reaction for the first time. With Pd (OAc) 2-X-Phos as the catalyst, a series of unsymmetric …
Palladium‐Catalyzed Regioselective Oxidative Annulation of Cyclohexanones and 2‐Aminophenyl Ketones Using Molecular Oxygen as the Sole Oxidant
WL Mu, M Wang, HJ Li, DM Huang… - Advanced Synthesis …, 2017 - Wiley Online Library
A facile oxidative annulation of cyclohexanones and 2‐aminophenyl ketones that uses
molecular oxygen as the sole oxidant is described. The reaction provides a direct approach …
molecular oxygen as the sole oxidant is described. The reaction provides a direct approach …
Targeted therapy in oncology patients and skin: Pharmaceutical and dermocosmetic management
A Varvaresou, K Iakovou, F Mellou… - Journal of Cosmetic …, 2020 - Wiley Online Library
Background Numerous oncology patients who receive targeted therapy suffer from the skin
adverse effects induced. Novel agents, that is tyrosine kinase inhibitors and RAS‐RAF‐MEK …
adverse effects induced. Novel agents, that is tyrosine kinase inhibitors and RAS‐RAF‐MEK …
Copper catalyzed coupling of protecting group free and sterically hindered 2-bromobenzyl tertiary alcohols with phenols and anilines: facile synthesis of xanthenes …
L Mahendar, G Satyanarayana - RSC advances, 2016 - pubs.rsc.org
A simple and efficient method for the synthesis of xanthenes and dihydroacridines
containing a quaternary carbon atom at the 9th-position, is presented. Significantly, the …
containing a quaternary carbon atom at the 9th-position, is presented. Significantly, the …