Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Free radicals generated within subcellular compartments damage macromolecules which
lead to severe structural changes and functional alterations of cellular organelles. A …

This brief resume enumerates the multiple actions of melatonin as an antioxidant. This
indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other …

The pineal product melatonin has remarkable antioxidant properties. It is secreted during
darkness and plays a key role in various physiological responses including regulation of …

Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

This review briefly summarizes the multiple actions by which melatonin reduces the
damaging effects of free radicals and reactive oxygen and nitrogen species. It is well …

Melatonin is a natural occurring compound with well‐known antioxidant properties.
Melatonin is ubiquitously distributed and because of its small size and amphiphilic nature, it …

Melatonin, or N‐acetyl‐5‐methoxytryptamine, is a compound derived from tryptophan that is
found in all organisms from unicells to vertebrates. This indoleamine may act as a protective …

Aerobic cells use oxygen for the production of 90–95% of the total amount of ATP that they
use. This amounts to about 40 kg ATP/day in an adult human. The synthesis of ATP via the …

Melatonin is a natural occurring compound with well-known antioxidant properties. In the
last decade a new effect of melatonin on mitochondrial homeostasis has been discovered …