Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in
patients with coronary heart disease. Myocardial ischemia simultaneously induces …

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two
decades has emphasized the inflammatory process as a key component in the …

Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …

Rationale: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been
shown to block cardiac fibrosis in preclinical models of heart failure (HF). However, since the …

Cardiovascular Disease (CVD) is the most common cause of death in industrialized
countries, and myocardial infarction (MI) is a major CVD with significant morbidity and …

Cardiac fibrosis is one of the major components of the healing mechanism following any
injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a …

The adult mammalian heart is thought to be a terminally differentiated organ given the
postmitotic nature of cardiomyocytes. Consequently, the potential for cardiac repair through …