Food antioxidants: chemical insights at the molecular level

A Galano, G Mazzone, R Alvarez-Diduk… - Annual review of …, 2016 - annualreviews.org
In this review, we briefly summarize the reliability of the density functional theory (DFT)-
based methods to accurately predict the main antioxidant properties and the reaction …

Neglected filoviruses

R Burk, L Bollinger, JC Johnson, J Wada… - FEMS microbiology …, 2016 - academic.oup.com
Eight viruses are currently assigned to the family Filoviridae. Marburg virus, Sudan virus
and, in particular, Ebola virus have received the most attention both by researchers and the …

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

TK Warren, J Wells, RG Panchal, KS Stuthman… - Nature, 2014 - nature.com
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case
fatality rates of filovirus disease outbreaks are among the highest reported for any human …

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

RM Deans, DW Morgens, A Ökesli, S Pillay… - Nature chemical …, 2016 - nature.com
Broad-spectrum antiviral drugs targeting host processes could potentially treat a wide range
of viruses while reducing the likelihood of emergent resistance. Despite great promise as …

Chitosan elicitation of Isatis tinctoria L. hairy root cultures for enhancing flavonoid productivity and gene expression and related antioxidant activity

J Jiao, QY Gai, X Wang, QP Qin, ZY Wang, J Liu… - Industrial crops and …, 2018 - Elsevier
Highlights•Chitosan elicitation was conducted for flavonoid enhancement in hairy root
cultures.•Chitosan elicitation gave a 7.08-fold increase in flavonoid yield over …

Advances in designing and developing vaccines, drugs, and therapies to counter Ebola virus

K Dhama, K Karthik, R Khandia, S Chakraborty… - Frontiers in …, 2018 - frontiersin.org
Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …

Antioxidant potential of antiviral drug umifenovir

EV Proskurnina, DY Izmailov, MM Sozarukova… - Molecules, 2020 - mdpi.com
Free radical reactions play an important role in biological functions of living systems. The
balance between oxidants and antioxidants is necessary for the normal homeostasis of cells …

Emerging targets and novel approaches to Ebola virus prophylaxis and treatment

JH Choi, MA Croyle - BioDrugs, 2013 - Springer
Ebola is a highly virulent pathogen causing severe hemorrhagic fever with a high case
fatality rate in humans and non-human primates (NHPs). Although safe and effective …

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses

Z Han, J Lu, Y Liu, B Davis, MS Lee, MA Olson… - Journal of …, 2014 - Am Soc Microbiol
Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host
proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains …

Ebola virus (EBOV) infection: therapeutic strategies

E De Clercq - Biochemical Pharmacology, 2015 - Elsevier
Within less than a year after its epidemic started (in December 2013) in Guinea, Ebola virus
(EBOV), a member of the filoviridae, has spread over a number of West-African countries …