Aging and the male reproductive system

JM Kaufman, B Lapauw, A Mahmoud… - Endocrine …, 2019 - academic.oup.com
This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

[HTML][HTML] Impact of testosterone on Alzheimer's disease

VE Bianchi - The World Journal of Men's Health, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disease responsible for almost half of all
dementia cases in the world and progressively increasing. The etiopathology includes …

[HTML][HTML] Management of patients with advanced prostate cancer: the report of the Advanced Prostate Cancer Consensus Conference APCCC 2017

S Gillessen, G Attard, TM Beer, H Beltran, A Bossi… - European urology, 2018 - Elsevier
Background In advanced prostate cancer (APC), successful drug development as well as
advances in imaging and molecular characterisation have resulted in multiple areas where …

Association of second-generation antiandrogens with cognitive and functional toxic effects in randomized clinical trials: a systematic review and meta-analysis

MK Nowakowska, RM Ortega, MR Wehner… - JAMA …, 2023 - jamanetwork.com
Importance The use of second-generation antiandrogens (AAs) in the treatment of prostate
cancer is increasing. Retrospective evidence suggests an association between second …

Association between androgen deprivation therapy use and diagnosis of dementia in men with prostate cancer

R Jayadevappa, S Chhatre, SB Malkowicz… - JAMA network …, 2019 - jamanetwork.com
Importance The association between androgen deprivation therapy (ADT) exposure and
dementia is uncertain. Objective To analyze the association between ADT exposure and …

Risks of major long‐term side effects associated with androgen‐deprivation therapy in men with prostate cancer

C Nguyen, DR Lairson, MD Swartz… - … : The Journal of Human …, 2018 - Wiley Online Library
Study Objective To examine the risks and compare the occurrences of major long‐term side
effects (sexual dysfunction, bone fractures, diabetes, cardiovascular morbidity, acute …

The risk of new onset dementia and/or Alzheimer disease among patients with prostate cancer treated with androgen deprivation therapy: a systematic review and …

R Sari Motlagh, F Quhal, K Mori, N Miura… - The Journal of …, 2021 - auajournals.org
Purpose: Androgen deprivation therapy is a standard therapy for some patients with
localized and almost all patients with metastatic prostate cancer. Although several clinical …

Causes of death after prostate cancer diagnosis: a population‐based study

Y Guo, X Dong, S Mao, F Yang, R Wang… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Mortality from noncancer causes in patients with prostate cancer (PCa) is
unclear. This study assesses the causes and risks of noncancer death with each follow‐up …

Androgen deprivation therapy for prostate cancer and dementia risk: a systematic review and meta-analysis

KT Nead, S Sinha, PL Nguyen - Prostate cancer and prostatic diseases, 2017 - nature.com
Background: Androgen deprivation therapy (ADT) to treat prostate cancer may be
associated with an increased risk of dementia, but existing studies have shown conflicting …

A systematic review on the potential acceleration of neurocognitive aging in older cancer survivors

C Kerstens, HPMW Wildiers, G Schroyen, M Almela… - Cancers, 2023 - mdpi.com
Simple Summary As survival rates for cancer increase and most patients exceed the age of
65 years, more emphasis has gone to possible cognitive sequelae, which could be …