Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae …

Recent evidence suggests that calorie restriction and specifically reduced glucose
metabolism induces mitochondrial metabolism to extend life span in various model …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

The past decade has seen fundamental advances in our understanding of the ageing
process and raised optimism that interventions to slow ageing may be on the horizon …

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the
whole body levels resulting in decreased functioning, development of diseases, and …

Age-associated changes within an individual are inherently complex and occur at multiple
levels of organismal function. The overall decline in function of various tissues is known to …

The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life
span (CLS) and the replicative life span (RLS). The chronological life span is a measure of …

Target of rapamycin complex 1 (TORC 1) is implicated in growth control and aging from
yeast to humans. Fission yeast is emerging as a popular model organism to study TOR …

Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown
functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent …