Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Natural killer (NK) cells play critical roles in host immunity against cancer. In response,
cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current …

Natural killer cells are important effector lymphocytes of the innate immune system, playing
critical roles in antitumor and anti-infection host defense. Tumor progression or chronic …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

Natural killer cell (NK cell)–based immunotherapy of cancer is hampered by the transient
effector function of NK cells. Recently, mouse IL-12/15/18–preactivated NK cells were shown …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Natural killer (NK) cells are innate effector lymphocytes necessary for defence against
stressed, microbe-infected, or malignant cells. NK cells kill target cells by either of two major …

Cellular transformation and tumor development result from an accumulation of mutational
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100 …