Reactive oxygen species and cancer: A complex interaction
Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …
Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer
Abrogation of endoplasmic reticulum (ER) protein folding triggered by exogenous or
endogenous factors, stimulates a cellular stress response, termed ER stress. ER stress re …
endogenous factors, stimulates a cellular stress response, termed ER stress. ER stress re …
Investigation of mitochondrial metabolic response to doxorubicin in prostate cancer cells: an NADH, FAD and tryptophan FLIM assay
Prostate cancer (PCa) is one of the leading cancers in men in the USA. Lack of experimental
tools that predict therapy response is one of the limitations of current therapeutic regimens …
tools that predict therapy response is one of the limitations of current therapeutic regimens …
Genetic and biological drivers of prostate cancer disparities in Black men
J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
Mitochondrial determinants of cancer health disparities
AR Choudhury, KK Singh - Seminars in cancer biology, 2017 - Elsevier
Mitochondria, which are multi-functional, have been implicated in cancer initiation,
progression, and metastasis due to metabolic alterations in transformed cells. Mitochondria …
progression, and metastasis due to metabolic alterations in transformed cells. Mitochondria …
Hsp60 and IL-8 axis promotes apoptosis resistance in cancer
S Kumar, J O'Malley, AK Chaudhary, JR Inigo… - British Journal of …, 2019 - nature.com
Abstract Background Interleukin-8 (IL-8) and heat shock protein 60 (Hsp60) play crucial
roles in cell survival and maintenance of cellular homoeostasis. However, cross talks …
roles in cell survival and maintenance of cellular homoeostasis. However, cross talks …
HSP60 in cancer: A promising biomarker for diagnosis and a potentially useful target for treatment
B Sun, G Li, Q Yu, D Liu, X Tang - Journal of Drug Targeting, 2022 - Taylor & Francis
Heat shock proteins (HSPs), most of which are molecular chaperones, are highly conserved
proteins produced by cells under physiological stress or pathological conditions. HSP60 (57 …
proteins produced by cells under physiological stress or pathological conditions. HSP60 (57 …
Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies
Abstract Background African Americans (AAs) in the United States are known to have a
higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological …
higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological …
Mitochondrial alterations in prostate cancer: roles in pathobiology and racial disparities
Prostate cancer (PCa) affects millions of men worldwide and is a major cause of cancer-
related mortality. Race-associated PCa health disparities are also common and are of both …
related mortality. Race-associated PCa health disparities are also common and are of both …
Mitochondrial biology and prostate cancer ethnic disparity
Prostate cancer remains the second most prevalent cancer in men. Its incidence,
progression and mortality profiles vary significantly by race and ethnicity, with African …
progression and mortality profiles vary significantly by race and ethnicity, with African …