Calcium imaging is emerging as a popular technique in neuroscience. A major reason is
that intracellular calcium transients are reflections of electrical events in neurons. For …

Learning induces the formation of new excitatory synapses in the form of dendritic spines,
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …

Neurons remodel the structure and strength of their synapses during critical periods of
development in order to optimize both perception and cognition. Many of these …

The active properties of dendrites can support local nonlinear operations, but previous
imaging and electrophysiological measurements have produced conflicting views regarding …

The structural organization of excitatory inputs supporting spike-timing-dependent plasticity
(STDP) remains unknown. We performed a spine STDP protocol using two-photon (2P) …

Electroencephalograms (EEGs) display a mixture of rhythmic and broadband fluctuations,
the latter manifesting as an apparent 1/f spectral trend. While network oscillations are known …

Single neocortical neurons are driven by populations of excitatory inputs, which form the
basis of neuronal selectivity to features of sensory input. Excitatory connections are thought …

Synaptic NMDA receptors can produce powerful dendritic supralinearities that expand the
computational repertoire of single neurons and their respective circuits. This form of …

Dendrites integrate inputs nonlinearly, but it is unclear how these nonlinearities contribute to
the overall input-output transformation of single neurons. We developed statistically …

Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of
synaptic inputs. However, their relationship to synaptic structure and functional activity is …