Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Gold nanoparticle-mediated lateral flow assays for detection of host antibodies and COVID-19 proteins

LS Ardekani, PW Thulstrup - Nanomaterials, 2022 - mdpi.com
Coronaviruses, that are now well-known to the public, include a family of viruses that can
cause severe acute respiratory syndrome (SARS) and other respiratory diseases, such as …

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA. 1, BA. 2, and BA. 4/5 and diverse sarbecoviruses

M Li, Y Ren, ZQ Aw, B Chen, Z Yang, Y Lei… - Nature …, 2022 - nature.com
Abstract As SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading
worldwide, development of antibodies and vaccines to confer broad and protective activity is …

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

L Hanke, H Das, DJ Sheward… - Nature …, 2022 - nature.com
Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
spike have therapeutic promise, but emerging variants show the potential for virus escape …

[HTML][HTML] Impaired immune response drives age-dependent severity of COVID-19

J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models

MA Rossotti, H van Faassen, AT Tran, J Sheff… - Communications …, 2022 - nature.com
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2.
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

NV Johnson, RC van Scherpenzeel… - Nature …, 2024 - nature.com
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human
populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion …

Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern

TR Wagner, D Schnepf, J Beer, N Ruetalo, K Klingel… - EMBO …, 2022 - embopress.org
The ongoing COVID‐19 pandemic and the emergence of new SARS‐CoV‐2 variants of
concern (VOCs) requires continued development of effective therapeutics. Recently, we …

First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants

A Titong, S Gallolu Kankanamalage, J Dong… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 and its variants have persisted in this ongoing COVID-19 pandemic. While the
vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half …

Anti-SARS-CoV-1 and− 2 nanobody engineering towards avidity-inspired therapeutics

EM Obeng, CKO Dzuvor, MK Danquah - Nano Today, 2022 - Elsevier
In the past two decades, the emergence of coronavirus diseases has been dire distress on
both continental and global fronts and has resulted in the search for potent treatment …