Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Gold nanoparticle-mediated lateral flow assays for detection of host antibodies and COVID-19 proteins
LS Ardekani, PW Thulstrup - Nanomaterials, 2022 - mdpi.com
Coronaviruses, that are now well-known to the public, include a family of viruses that can
cause severe acute respiratory syndrome (SARS) and other respiratory diseases, such as …
cause severe acute respiratory syndrome (SARS) and other respiratory diseases, such as …
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA. 1, BA. 2, and BA. 4/5 and diverse sarbecoviruses
Abstract As SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading
worldwide, development of antibodies and vaccines to confer broad and protective activity is …
worldwide, development of antibodies and vaccines to confer broad and protective activity is …
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
L Hanke, H Das, DJ Sheward… - Nature …, 2022 - nature.com
Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
spike have therapeutic promise, but emerging variants show the potential for virus escape …
spike have therapeutic promise, but emerging variants show the potential for virus escape …
[HTML][HTML] Impaired immune response drives age-dependent severity of COVID-19
J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2.
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies
NV Johnson, RC van Scherpenzeel… - Nature …, 2024 - nature.com
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human
populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion …
populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion …
Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern
TR Wagner, D Schnepf, J Beer, N Ruetalo, K Klingel… - EMBO …, 2022 - embopress.org
The ongoing COVID‐19 pandemic and the emergence of new SARS‐CoV‐2 variants of
concern (VOCs) requires continued development of effective therapeutics. Recently, we …
concern (VOCs) requires continued development of effective therapeutics. Recently, we …
First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants
A Titong, S Gallolu Kankanamalage, J Dong… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 and its variants have persisted in this ongoing COVID-19 pandemic. While the
vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half …
vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half …
Anti-SARS-CoV-1 and− 2 nanobody engineering towards avidity-inspired therapeutics
In the past two decades, the emergence of coronavirus diseases has been dire distress on
both continental and global fronts and has resulted in the search for potent treatment …
both continental and global fronts and has resulted in the search for potent treatment …