Viral Z-RNA triggers ZBP1-dependent cell death
S Balachandran, ES Mocarski - Current opinion in virology, 2021 - Elsevier
Z-DNA Binding protein 1 (ZBP1) activates Receptor Interacting Protein Kinase 3 (RIPK3)-
dependent cell death during lytic infection by members of the orthomyxovirus, herpesvirus …
dependent cell death during lytic infection by members of the orthomyxovirus, herpesvirus …
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
Structure and formation of Z-DNA and Z-RNA
Despite structural differences between the right-handed conformations of A-RNA and B-
DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their …
DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their …
[HTML][HTML] Influenza virus Z-RNAs induce ZBP1-mediated necroptosis
Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-
protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain …
protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain …
Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA
when bound by Zα domains found within a variety of innate immune response proteins. Zα …
when bound by Zα domains found within a variety of innate immune response proteins. Zα …
Oligonucleotides DNA containing 8-trifluoromethyl-2′-deoxyguanosine for observing Z-DNA structure
HL Bao, T Masuzawa, T Oyoshi, Y Xu - Nucleic Acids Research, 2020 - academic.oup.com
Z-DNA is known to be a left-handed alternative form of DNA and has important biological
roles as well as being related to cancer and other genetic diseases. It is therefore important …
roles as well as being related to cancer and other genetic diseases. It is therefore important …
A genetic instruction code based on DNA conformation
A Herbert - Trends in Genetics, 2019 - cell.com
Flipons are sequences capable of forming either right-or left-handed DNA under
physiological conditions, forming a class of dissipative structures that trade metabolic energy …
physiological conditions, forming a class of dissipative structures that trade metabolic energy …
Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis
S Mishra, AA Dey, S Kesavardhana - Immunological Reviews, 2025 - Wiley Online Library
ABSTRACT Z‐nucleic acid binding protein 1 (ZBP1) is an innate immune sensor
recognizing nucleic acids in Z‐conformation. Upon Z‐nucleic acid sensing, ZBP1 triggers …
recognizing nucleic acids in Z‐conformation. Upon Z‐nucleic acid sensing, ZBP1 triggers …
Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions
Recent findings in cell biology have rekindled interest in Z-DNA, the left-handed helical form
of DNA. We report here that two minimally modified nucleosides, 2′ F-araC and 2′ F …
of DNA. We report here that two minimally modified nucleosides, 2′ F-araC and 2′ F …
A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion
MA Diallo, S Pirotte, Y Hu, L Morvan… - Nucleic Acids …, 2023 - academic.oup.com
Zalpha (Zα) domains bind to left-handed Z-DNA and Z-RNA. The Zα domain protein family
includes cellular (ADAR1, ZBP1 and PKZ) and viral (vaccinia virus E3 and cyprinid …
includes cellular (ADAR1, ZBP1 and PKZ) and viral (vaccinia virus E3 and cyprinid …