Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing
neoplasms. Conventional chondrosarcomas are a continuum of disease based on the …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the
second most frequent malignant bone tumor. Due to its resistance to chemo-and …

Sarcomas are known as a heterogeneous class of cancers arisen in the connective tissues
and demonstrated various histological subtypes including both soft tissue and bone origin …

Background This single‐arm, multicenter, phase 2 study evaluated the safety and antitumor
activity of pazopanib in patients with unresectable or metastatic conventional …

Bone sarcomas, although rare, are associated with significant morbidity and mortality. The
most frequent primary bone cancers include osteosarcoma, chondrosarcoma and Ewing …

Soft tissue and bone sarcomas are malignancies of mesenchymal origin, and more than 50
subtypes are defined. For most sarcomas, locally advanced or unresectable disease is still …

Unlike other malignant bone tumors including osteosarcomas and Ewing sarcomas with a
peak incidence in adolescents and young adults, conventional and dedifferentiated …

Bone sarcomas are primary bone tumours found mainly in children and adolescents, as
osteosarcoma and Ewing's sarcoma, and in adults in their 40s as chondrosarcoma. The last …

Osteoclasts are highly specialized cells of the bone, with a unique apparatus responsible for
resorption in the process of bone remodeling. They are derived from differentiation and …