[HTML][HTML] New strategies against drug resistance to herpes simplex virus

YC Jiang, H Feng, YC Lin, XR Guo - International journal of oral …, 2016 - nature.com
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human
pathogen that results in mucocutaneous lesions in the oral cavity or genital infections …

How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients

F El Chaer, DP Shah… - Blood, The Journal of the …, 2016 - ashpublications.org
Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Definitions of resistant and refractory cytomegalovirus infection and disease in transplant recipients for use in clinical trials

RF Chemaly, S Chou, H Einsele… - Clinical Infectious …, 2019 - academic.oup.com
Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major
complication in solid organ and hematopoietic cell transplant recipients. CMV infection may …

Drug resistance assessed in a phase 3 clinical trial of maribavir therapy for refractory or resistant cytomegalovirus infection in transplant recipients

S Chou, S Alain, C Cervera, RF Chemaly… - The Journal of …, 2024 - academic.oup.com
Background This drug resistance analysis of a randomized trial includes 234 patients
receiving maribavir and 116 receiving investigator-assigned standard therapy (IAT), where …

Detection of cytomegalovirus drug resistance mutations by next-generation sequencing

MK Sahoo, MI Lefterova, F Yamamoto… - Journal of clinical …, 2013 - Am Soc Microbiol
Antiviral therapy for cytomegalovirus (CMV) plays an important role in the clinical
management of solid organ and hematopoietic stem cell transplant recipients. However …

The biology of cytomegalovirus drug resistance

M Hakki, S Chou - Current opinion in infectious diseases, 2011 - journals.lww.com
An increasing volume of information correlating CMV genotypes and drug susceptibility
phenotypes is becoming available. This will improve the interpretation of sequence-based …

[HTML][HTML] Detection of low frequency multi-drug resistance and novel putative maribavir resistance in immunocompromised pediatric patients with cytomegalovirus

CJ Houldcroft, JM Bryant, DP Depledge… - Frontiers in …, 2016 - frontiersin.org
Human cytomegalovirus (HCMV) is a significant pathogen in immunocompromised
individuals, with the potential to cause fatal pneumonitis and colitis, as well as increasing the …

Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art

AB Campos, J Ribeiro, D Boutolleau… - Reviews in medical …, 2016 - Wiley Online Library
Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in
allogeneic hematopoietic stem cell transplant recipients. The significant clinical impact of …

Resistance of human cytomegalovirus to ganciclovir/valganciclovir: a comprehensive review of putative resistance pathways

TE Komatsu, A Pikis, LK Naeger, PR Harrington - Antiviral research, 2014 - Elsevier
Human cytomegalovirus (HCMV) is a pathogen that can be life-threatening in
immunocompromised individuals. Valganciclovir and its parent drug ganciclovir are …

Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity

H Chen, GP Beardsley… - Proceedings of the …, 2014 - National Acad Sciences
Many antiviral and anticancer drugs are nucleoside analogs that target polymerases and
cause DNA chain termination. Interestingly, ganciclovir (GCV), the first line of therapy for …