[HTML][HTML] Antibiotics produced by Streptomyces

REL Procópio, IR Silva, MK Martins… - Brazilian Journal of …, 2012 - SciELO Brasil
Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and
its shape resembles filamentous fungi. The morphological differentiation of Streptomyces …

Molecular regulation of antibiotic biosynthesis in Streptomyces

G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

C Olano, F Lombo, C Mendez, JA Salas - Metabolic engineering, 2008 - Elsevier
Production of secondary metabolites is a process influenced by several physico-chemical
factors including nutrient supply, oxygenation, temperature and pH. These factors have been …

Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth

CD Den Hengst, NT Tran, MJ Bibb… - Molecular …, 2010 - Wiley Online Library
BldD is a transcriptional regulator essential for morphological development and antibiotic
production in Streptomyces coelicolor. Here we identify the BldD regulon by means of …

The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining

H Xia, X Li, Z Li, X Zhan, X Mao, Y Li - Frontiers in microbiology, 2020 - frontiersin.org
Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …

Towards a new science of secondary metabolism

A Craney, S Ahmed, J Nodwell - The Journal of antibiotics, 2013 - nature.com
Secondary metabolites are a reliable and very important source of medicinal compounds.
While these molecules have been mined extensively, genome sequencing has suggested …

A Cellulose Synthase-Like Protein Involved in Hyphal Tip Growth and Morphological Differentiation in Streptomyces

H Xu, KF Chater, Z Deng, M Tao - Journal of bacteriology, 2008 - Am Soc Microbiol
Cellulose synthase and cellulose synthase-like proteins, responsible for synthesizing β-
glucan-containing polysaccharides, play a fundamental role in cellular architectures, such …

Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H

W Chen, T Huang, X He, Q Meng, D You, L Bai… - Journal of Biological …, 2009 - ASBMB
A gene cluster (pol) essential for the biosynthesis of polyoxin, a nucleoside antibiotic widely
used for the control of phytopathogenic fungi, was cloned from Streptomyces cacaoi. A …