Targeting the epigenetic regulation of antitumour immunity
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …
cancer onset and progression. Although defective gene regulation often affects oncogenic …
Generative models for de novo drug design
Artificial intelligence (AI) is booming. Among various AI approaches, generative models
have received much attention in recent years. Inspired by these successes, researchers are …
have received much attention in recent years. Inspired by these successes, researchers are …
Machine learning for perovskite solar cells and component materials: key technologies and prospects
Data‐driven epoch, the development of machine learning (ML) in materials and device
design is an irreversible trend. Its ability and efficiency to handle nonlinear and game …
design is an irreversible trend. Its ability and efficiency to handle nonlinear and game …
Graph neural networks for automated de novo drug design
Highlights•GNN has attracted wide attention from the field of designing drug molecules.•The
applications of GNN in molecule scoring, molecule generation and optimization, and …
applications of GNN in molecule scoring, molecule generation and optimization, and …
Generative deep learning for targeted compound design
In the past few years, de novo molecular design has increasingly been using generative
models from the emergent field of Deep Learning, proposing novel compounds that are …
models from the emergent field of Deep Learning, proposing novel compounds that are …
[HTML][HTML] Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
Q Chen, B Yang, X Liu, XD Zhang, L Zhang, T Liu - Theranostics, 2022 - ncbi.nlm.nih.gov
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …
sequence homology and functional overlap and co-operation, are emerging as critical …
Acetylation targeting chimera enables acetylation of the tumor suppressor p53
With advances in chemically induced proximity technologies, heterobifunctional modalities
such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to …
such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to …
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and
KAT3B) maintain gene expression programs through lysine acetylation of chromatin and …
KAT3B) maintain gene expression programs through lysine acetylation of chromatin and …
Current development of CBP/p300 inhibitors in the last decade
ZX He, BF Wei, X Zhang, YP Gong, LY Ma… - European Journal of …, 2021 - Elsevier
CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …
represents an attractive target for various diseases, including malignant tumor. The …
Multi-objective goal-directed optimization of de novo stable organic radicals for aqueous redox flow batteries
Advances in the field of goal-directed molecular optimization offer the promise of finding
feasible candidates for even the most challenging molecular design applications. One …
feasible candidates for even the most challenging molecular design applications. One …