Emergence of form and function during embryogenesis arises in large part through cell-type-
and cell-state-specific variation in gene expression patterns, mediated by specialized cis …

Histones are essential proteins that package the eukaryotic genome into its physiological
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …

Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive
phenotypes of tumor-infiltrating immune cells. We report herein that interleukin-4 (IL-4) …

Asthma is prevalent in Western countries, and recent explanations have evoked the actions
of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut …

Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for
small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 …

O-GlcNAc is a dynamic post-translational modification (PTM) that regulates protein functions.
In studying the regulatory roles of O-GlcNAc, a major roadblock is the inability to change O …

De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein
(ADNP), have recently been found to underlie Helsmoortel–Van der Aa syndrome, a …

Histones are highly covalently modified, but the functions of many of these modifications
remain unknown. In particular, it is unclear how histone marks are coupled to cellular …

Cerebral ischemia leads to neuroinflammation and activation of microglia which further
contribute to stroke pathology. Understanding regulation of microglial activation will aid in …

JCI - Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and
learning-dependent transcription Go to JCI Insight About Editors Consulting Editors For authors …