Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …

This review focuses on fibrin, starting from biological mechanisms (its production from
fibrinogen and its enzymatic degradation), through its use as a medical device and as a …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …

Helical nanofibres play key roles in many biological processes. Entanglements between
helices can aid gelation by producing thick, interconnected fibres, but the details of this …

In contrast to most synthetic hydrogels, biological gels are made of fibrous networks. This
architecture gives rise to unique properties, like low concentration, high porosity gels with a …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is
characterized by formation of obstructive intravascular clots (thrombi) and their mechanical …

Biomimetic, strain‐stiffening materials are reported, made through self‐assembly and
covalent fixation of small building blocks to form fibrous hydrogels that are able to stiffen by …

Polymeric fibrin displays unique structural and biomechanical properties that contribute to its
essential role of generating blood clots that stem bleeds. The aim of this review is to discuss …

We present theoretical and experimental studies of the elastic response of fibrous networks
subjected to uniaxial strain. Uniaxial compression or extension is applied to extracellular …