Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

This review is based on a presentation given at the Hans Popper Hepatopathology Society
companion meeting at the 2019 United States and Canadian Academy of Pathology Annual …

The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

The latest World Health Organization (WHO) classification from 2015 has grouped lung and
thymic neuroendocrine tumours (NETs)(named neoplasm in the digestive WHO …

Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed
throughout the bronchial epithelium, many in innervated clusters of 20–30 cells. Following …

Molecular heterogeneity is a frequent event in cancer responsible of several critical issues in
diagnosis and treatment of oncologic patients. Lung tumours are characterized by high …

Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Purpose: Previous genomic studies have identified two mutually exclusive molecular
subtypes of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly …

The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …