Abstract The Open Targets Platform (https://www. targetvalidation. org/) provides users with
a queryable knowledgebase and user interface to aid systematic target identification and …

Functional genomics approaches can overcome limitations—such as the lack of
identification of robust targets and poor clinical efficacy—that hamper cancer drug …

Abstract The Open Targets Platform integrates evidence from genetics, genomics,
transcriptomics, drugs, animal models and scientific literature to score and rank target …

Tumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection,
relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous …

Cancer progression has been attributed to somatic changes in single-nucleotide variants,
copy-number aberrations, loss of heterozygosity, chromosomal instability, epistatic …

The remarkable genetic heterogeneity of multiple myeloma poses a substantial challenge
for proper prognostication and clinical management of patients. Here, we introduce MM …

The druggable proteome refers to proteins that can bind to small molecules with appropriate
chemical affinity, inducing a favorable clinical response. Predicting druggable proteins …

Sporadic gliomas in companion dogs provide a window on the interaction between
tumorigenic mechanisms and host environment. We compared the molecular profiles of …

Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-
stained tumor slides for precision oncology. We present ENLIGHT–DeepPT, an indirect two …

Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable
recurrences and dismal outcomes. Here, we present an integrated analysis of the whole …