A review of curcumin and its derivatives as anticancer agents

MA Tomeh, R Hadianamrei, X Zhao - International journal of molecular …, 2019 - mdpi.com
Cancer is the second leading cause of death in the world and one of the major public health
problems. Despite the great advances in cancer therapy, the incidence and mortality rates of …

Potential role of curcumin and its nanoformulations to treat various types of cancers

MT Kabir, MH Rahman, R Akter, T Behl, D Kaushik… - Biomolecules, 2021 - mdpi.com
Cancer is a major burden of disease globally. Each year, tens of millions of people are
diagnosed with cancer worldwide, and more than half of the patients eventually die from it …

The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - Elsevier
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Potential anticancer properties and mechanisms of action of curcumin

NG Vallianou, A Evangelopoulos, N Schizas… - Anticancer …, 2015 - ar.iiarjournals.org
Curcumin, a yellow substance belonging to the polyphenols superfamily, is the active
component of turmeric, a common Indian spice, which is derived from the dried rhizome of …

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults

SR Rainey-Smith, BM Brown, HR Sohrabi… - British Journal of …, 2016 - cambridge.org
Curcumin therapy in animals has produced positive cognitive and behavioural outcomes;
results of human trials, however, have been inconsistent. In this study, we report the results …

Mechanism insights of curcumin and its analogues in cancer: An update

P Joshi, K Verma, D Kumar Semwal… - Phytotherapy …, 2023 - Wiley Online Library
Cancer is the world's second leading cause of mortality and one of the major public health
problems. Cancer incidence and mortality rates remain high despite the great …

Hybrid curcumin compounds: a new strategy for cancer treatment

MH Teiten, M Dicato, M Diederich - Molecules, 2014 - mdpi.com
Cancer is a multifactorial disease that requires treatments able to target multiple intracellular
components and signaling pathways. The natural compound, curcumin, was already …

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

SU Gandhy, KH Kim, L Larsen, RJ Rosengren, S Safe - BMC cancer, 2012 - Springer
Background Curcumin inhibits growth of several cancer cell lines, and studies in this
laboratory in bladder and pancreatic cancer cells show that curcumin downregulates …

Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy

M Mimeault, SK Batra - Chinese medicine, 2011 - Springer
Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to
its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities …

Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

NA Torbat, I Akbarzadeh, N Rezaei… - Coordination Chemistry …, 2023 - Elsevier
Curcumin (diferuloylmethane) is the main constituent extracted from turmeric. This
polyphenol is a non-toxic, potent compound with anticancer, anti-inflammatory, antibacterial …