Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies

G Olshansky, C Giles, A Salim, PJ Meikle - Progress in Lipid Research, 2022 - Elsevier
Large 'omics studies are of particular interest to population and clinical research as they
allow elucidation of biological pathways that are often out of reach of other methodologies …

[HTML][HTML] Lipidomics analysis in drug discovery and development

S Kostidis, E Sánchez-López, M Giera - Current Opinion in Chemical …, 2023 - Elsevier
Despite being a relatively new addition to the Omics' landscape, lipidomics is increasingly
being recognized as an important tool for the identification of druggable targets and …

Cross-laboratory standardization of preclinical lipidomics using differential mobility spectrometry and multiple reaction monitoring

M Ghorasaini, Y Mohammed, J Adamski… - Analytical …, 2021 - ACS Publications
Modern biomarker and translational research as well as personalized health care studies
rely heavily on powerful omics' technologies, including metabolomics and lipidomics …

[HTML][HTML] Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks

E Villain, A Chanson, M Mainka, N Kampschulte… - Iscience, 2023 - cell.com
Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly
on cytokines. Here, using a standardized whole-blood stimulation system, we characterized …

Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues

C Morisseau, SD Kodani, SG Kamita, J Yang… - International journal of …, 2021 - mdpi.com
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …

The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria

C Dalle, J Tournayre, M Mainka… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) is a complex condition encompassing a constellation of
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …

Esterified Oxylipins: Do They Matter?

CE Annevelink, RE Walker, GC Shearer - Metabolites, 2022 - mdpi.com
Oxylipins are oxygenated metabolites of fatty acids that share several similar biochemical
characteristics and functions to fatty acids including transport and trafficking. Oxylipins are …

The role of oxylipins and their validation as biomarkers in the clinical context

SM Camunas-Alberca, M Moran-Garrido, J Sáiz… - TrAC Trends in …, 2023 - Elsevier
Oxylipins are bioactive lipid mediators that participate in a wide range of processes, from
blood flow to inflammation. In recent years, their exhaustive characterization as potential …

HPLC-MS/MS oxylipin analysis of plasma from amyotrophic lateral sclerosis patients

M Mastrogiovanni, A Trostchansky, H Naya… - Biomedicines, 2022 - mdpi.com
Oxylipins play a critical role in regulating the onset and resolution phase of inflammation.
Despite inflammation is a pathological hallmark in amyotrophic lateral sclerosis (ALS), the …

Exploring oxylipins in processed foods: Understanding mechanisms, analytical perspectives, and enhancing quality with lipidomics

PW Harlina, V Maritha, X Yang, R Dixon, M Muchtaridi… - Heliyon, 2024 - cell.com
Oxylipins are active lipid compounds formed through the oxidation of unsaturated fatty acids.
These compounds have drawn considerable attention due to the potential impact on human …