Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies
Large 'omics studies are of particular interest to population and clinical research as they
allow elucidation of biological pathways that are often out of reach of other methodologies …
allow elucidation of biological pathways that are often out of reach of other methodologies …
[HTML][HTML] Lipidomics analysis in drug discovery and development
Despite being a relatively new addition to the Omics' landscape, lipidomics is increasingly
being recognized as an important tool for the identification of druggable targets and …
being recognized as an important tool for the identification of druggable targets and …
Cross-laboratory standardization of preclinical lipidomics using differential mobility spectrometry and multiple reaction monitoring
M Ghorasaini, Y Mohammed, J Adamski… - Analytical …, 2021 - ACS Publications
Modern biomarker and translational research as well as personalized health care studies
rely heavily on powerful omics' technologies, including metabolomics and lipidomics …
rely heavily on powerful omics' technologies, including metabolomics and lipidomics …
[HTML][HTML] Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks
E Villain, A Chanson, M Mainka, N Kampschulte… - Iscience, 2023 - cell.com
Oxylipins are major immunomodulating mediators, yet studies of inflammation focus mainly
on cytokines. Here, using a standardized whole-blood stimulation system, we characterized …
on cytokines. Here, using a standardized whole-blood stimulation system, we characterized …
Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria
C Dalle, J Tournayre, M Mainka… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) is a complex condition encompassing a constellation of
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …
Esterified Oxylipins: Do They Matter?
CE Annevelink, RE Walker, GC Shearer - Metabolites, 2022 - mdpi.com
Oxylipins are oxygenated metabolites of fatty acids that share several similar biochemical
characteristics and functions to fatty acids including transport and trafficking. Oxylipins are …
characteristics and functions to fatty acids including transport and trafficking. Oxylipins are …
The role of oxylipins and their validation as biomarkers in the clinical context
SM Camunas-Alberca, M Moran-Garrido, J Sáiz… - TrAC Trends in …, 2023 - Elsevier
Oxylipins are bioactive lipid mediators that participate in a wide range of processes, from
blood flow to inflammation. In recent years, their exhaustive characterization as potential …
blood flow to inflammation. In recent years, their exhaustive characterization as potential …
HPLC-MS/MS oxylipin analysis of plasma from amyotrophic lateral sclerosis patients
M Mastrogiovanni, A Trostchansky, H Naya… - Biomedicines, 2022 - mdpi.com
Oxylipins play a critical role in regulating the onset and resolution phase of inflammation.
Despite inflammation is a pathological hallmark in amyotrophic lateral sclerosis (ALS), the …
Despite inflammation is a pathological hallmark in amyotrophic lateral sclerosis (ALS), the …
Exploring oxylipins in processed foods: Understanding mechanisms, analytical perspectives, and enhancing quality with lipidomics
Oxylipins are active lipid compounds formed through the oxidation of unsaturated fatty acids.
These compounds have drawn considerable attention due to the potential impact on human …
These compounds have drawn considerable attention due to the potential impact on human …