Orlistat, an inhibitor of intestinal lipase, promotes body weight reduction. The lipid-lowering
efficacy of orlistat is controversial and the effect of orlistat-induced body weight reduction on …

The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2,
and PON3. Originating from the same fungus lactonase precursor, all of the three PON …

Obesity is typically linked to oxidative stress and inflammation, which lead to vascular
damage and initiate the progression of atherosclerosis. The aim of this study was to …

Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …

Abstract Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is
physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL …

Background: Obesity has rapidly become a life-threatening epidemic worldwide. There are a
plethora of obesity-related co-morbidities and complications that increase morbidity …

Abstract Objective Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a
high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis …

Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum
paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in …

The wide acceptance of the oxidation theory of atherogenesis has prompted attention to
antioxidant mechanisms, particularly the prevention of lipid oxidation by high-density …

The aim of this study was to examine the relationship between the L55M and Q192R
paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers …