The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut
homeostasis and their deficiency is involved in the pathogenesis of several disorders …

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Abstract Purpose of this Review This review assesses the latest evidence linking short-chain
fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and …

Diabetic kidney disease (DKD) is a progressive disorder, which is increasing globally in
prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal …

Mental disorders and neurological diseases are becoming a rapidly increasing medical
burden. Although extensive studies have been conducted, the progress in developing …

There is now a wealth of evidence showing that communication between microbiota and the
host is critical to sustain the vital functions of the healthy host, and disruptions of this …

Diabetes and obesity are metabolic diseases that have become alarming conditions in
recent decades. Their rate of increase is becoming a growing concern worldwide. Recent …