The generation of phagosomal cytotoxic reactive species (ie, free radicals and oxidants) by
activated macrophages and neutrophils is a crucial process for the control of intracellular …

Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a
major threat to public health, especially in middle and low-income countries. Worldwide in …

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium
tuberculosis (MTB) and it represents a persistent public health threat for a number of …

A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence
of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) …

Macrophages play a central role in tuberculosis, as the site of primary infection, inducers
and effectors of inflammation, innate and adaptive immunity, as well as mediators of tissue …

Indole-containing small molecules have been reported to have diverse pharmacological
activities. The aromatic heterocyclic scaffold, which resembles various protein structures …

Natural products provide a rich source of potential antimicrobials for treating infectious
diseases for which drug resistance has emerged. Foremost among these diseases is …

Tuberculosis (TB) remains one of the deadliest infectious diseases caused by
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …

Tuberculosis is the leading cause of mortality by infectious agents worldwide. The necrotic
debris, known as caseum, which accumulates in the center of pulmonary lesions and …